Jobs

We seek a talented and highly motivated postdoc to join our collaborative team jointly led by Drs. Parisa Shooshtari and Christopher Pin to study the epigenetic mechanisms of pancreatic cancer. The ideal candidate should have extensive experience with the analysis of next generation sequencing data, and is enthusiastic to apply advanced bioinformatics analysis to multi-omics data to uncover the cellular and molecular mechanisms of the disease. This postdoctoral position provides a unique opportunity to receive training in a world-class setting and in collaboration with scientists from Ontario Institute for Cancer Research (OICR), Western University Schulich School of Medicine and Dentistry, and the University of Michigan and Henry Ford Clinic in Detroit. This project is funded by MITACS, CIHR, and NSERC as well as provincial and local sources. Competitive salaries will be available to the successful candidate and commiserate with their level of experience.

Applications are invited for a  temporary  post of a Post-doctoral Research Fellow Level 1  or Level 2 within UCD School of Biomolecular and Biomedical Science.

The Chromatin Architecture in Cancer laboratory at University College Dublin, led by Dr. Eric Conway,  are recruiting a postdoctoral fellow to work on the role of chromatin regulators in acute myeloid leukemia. This position will be funded through a Science Foundation Ireland/ Irish Research Council Pathway Program award.

Project description

Driver mutations in epigenetic regulators such as DNMT3A, BCOR, EZH2, ASXL1 and TET2 occur in over 40% of acute myeloid leukaemias and tend to occur in patients with poor prognosis. The effect of these mutations on chromatin architecture, the epigenome and transcriptome is incompletely understood. Deciphering the mechanism of these mutations is critical in order to identify targeted therapeutics for these patients. Using a combination of in vitro and primary patient samples, this project will establish model systems to investigate these mechanisms in depth. This will involve analysis and integration of next-generation sequencing data from techniques such as RNA-seq, ChIP-seq, Hi-C and CUT&Tag. This inter-disciplinary project will involve close collaboration with clinical haematologists at St. James’s hospital, wet-lab & computational biologists and international research groups. Relevant recent publications from our group include Doyle et al, Frontiers in Cell & Dev Bio (2022), Conway et al, Molecular Cell (2021), Tamburri et al, Molecular Cell (2020), and Conway et al, Molecular Cell (2018).

Lab description

The Chromatin Architecture in Cancer laboratory is focused on leveraging mechanistic understanding of chromatin and epigenetic pathways to identify novel therapeutic targets in cancer. We pursue this goal through two means; 1) Use of isogenic disease model systems to explore disrupted epigenetic pathways, and 2) leveraging epigenomic mapping studies from patient samples to identify essential transcription factors and pathways that can be therapeutically targeted. The group is affiliated with the UCD School of Biomolecular and Biomedical Sciences, and the UCD Conway Institute of Biomolecular and Biomedical Research. Our group is located in the Conway Institute, an interdisciplinary research centre exploring the mechanisms of health and disease towards the development of preventative strategies and novel diagnostic and therapeutic solutions.

This is a research focused role, where you will conduct a specified programme of research supported by research training and development under the supervision and direction of a Principal Investigator.

The primary purpose of the role is to further develop your research skills and competences, including the processes of publication in peer-reviewed academic publications, the development of funding proposals, the mentorship of graduate students along with the opportunity to develop your skills in research led teaching.

Salary range: €39,522 – €44,350 per annum.

Appointment on the above range will be dependent upon qualifications and experience.

Closing date: 17:00hrs (local Irish time) on 19^th May 2023

Applications must be submitted by the closing date and time specified.

Any applications which are still in progress at the closing time of 17:00hrs (Local Irish Time) on the specified closing date will be cancelled automatically by the system. 

UCD are unable to accept late applications.

UCD do not require assistance from Recruitment Agencies.

Any CV’s submitted by Recruitment Agencies will be returned.

Prior to application, further information (including application procedure) should be obtained from the Work at UCD website: https://www.ucd.ie/workatucd/jobs/Bottom of Form

The Lettre lab at the Université de Montréal and the Montreal Heart Institute is looking for a postdoctoral fellow (or research associate) in computational human genetics to advance research in the study of blood diseases. Our lab has access to some of the largest genetic datasets and is part of an international collaborative network that focuses on the identification of novel genetic associations, genes and pathways that control non-malignant hematological diseases. The candidate will contribute to one or more CIHR- or NIH/NHGRI-funded projects using whole-genome sequencing, single-cell RNA-Seq, and proteomics data. Analysis tasks include: (1) genetic association analysis in multi-ancestry samples for blood-cell phenotypes, (2) biomarker and drug target prioritization in sickle cell disease using molecular data (including single-cell RNA-seq and proteomic data) and advanced methodologies (e.g. Mendelian randomization), and (3) optimization of polygenic risk scores for blood disorders.

Over the years, our team at University Health Network (UHN), University of Toronto, led by Sangeet Ghai, has developed methods for MR guided laser thermal therapy for localized prostate cancer. We propose treatment planning software that optimizes the ablation protocol for individual patients providing precise targeting of the tumor volume and improved preservation of surrounding healthy tissues. For future clinical trials, this requires a new tool to plan the placement of fiberoptics within the target tissue ensuring an optimal heating pattern. Topics of the postdoc’s research and daily work include:

• Implementation of software for generating optimal needle placement patterns, which must be adjustable by the clinician to account for interventional constraints
• Selecting suitable laser power parameters and modelling of the resulting regions of cell death
• Analysis of needle deflection data to identify an approach for deflection compensation or mitigation
• Detection and compensation for patient motion during the procedure
• Extending MR thermography software to provide robust, accurate, and reliable treatment monitoring
• Analyse the potential in reduction in treatment times
• Segmentation of anatomical structures and data analysis
• Experience in MRI would be advantageous
• Shadowing clinical procedures
• Writing manuscripts

Join our team as we integrate large-scale, genomic data and computational approaches to understand and predict psychiatric outcomes in clinical-treatment cohorts!

Applications are invited for a Postdoctoral Fellow position at the Pharmacogenetics Research Clinic at the Centre for Addiction and Mental Health and the University of Toronto, under the joint supervision of Dr. Daniel Mueller (M.D., Ph.D.) and Dr. Daniel Felsky (Ph.D.). The postdoctoral fellow will integrate psychiatric pharmacogenetics with various methods in computational biology and bioinformatics. Our primary goal is to understand and optimize the methodological opportunities and challenges for machine learning associated with the integration of genome-wide data from large-scale, epidemiological datasets and smaller, clinical-treatment cohorts. The postdoctoral fellow will engage in projects that aim to understand the genetic contributions to antidepressant non-remission in adults with depression and other psychiatric disorders within the context of underlying pathophysiology associated with aging and cerebrovascular and neurodegenerative changes.