Institution/Company:

University of Calgary

Location:

Calgary

, Alberta

 Canada

Job Type:

Postdoctoral

Degree Level Required:

PhD

175 days ago Apply now

Description:

Successful candidates will be recent PhD graduates who are interested in making fundamental discoveries in tumor evolution and immune response that can lead to translational impact in aggressive and largely incurable cancers.

Research approaches in our team include computational analyses of tumor multi-omic profiles at bulk and single cell level, with spatial and temporal resolution within patient samples. We are interested in how tumor cells cooperate with non-neoplastic cells of the microenvironment to respond to selective pressures in general, and in particular to standard therapy regimes. The focus of the candidate will be on establishing methods to integrate long-read sequencing data into our current workflows for genome and transcriptome analyses. Key goals include identification of novel biomarkers and targets for therapy that can be further pursued within a fully operational preclinical pipeline toward clinical translation.

The lab is part of a multi-disciplinary team of cancer researchers filled with passionate and determined individuals who will provide the successful candidate with a stimulating and conducive environment to participate and grow as a scientist. The research is conducted at the University of Calgary, in close collaboration with local and international scientists and clinicians, and thus will also provide the successful candidate with opportunities to learn from a large network of talented professionals.

Responsibilities:

The PDF will lead analyses of genome and transcriptome data from patient samples, profiled at bulk or single single cell resolution, and with a focus on long-read technologies. The candidate will use statistical and machine learning approaches to interpret data in the context of tumor evolution, with the aim of (1) understanding the dynamics of tumor growth, relapse, metastasis and progression, and (2) defining novel biomarkers of progression and targets for rational therapy. The PDF will design and carry out computational experiments and lead the writing of scientific manuscripts.

Qualifications:

  • PhD with training in bioinformatics, computer science, statistics or cell biology
  • Experience working in a Unix and HPC environment (shell scripting, command-line tools)
  • Experience conducting large-scale data analyses (genomic/multi-omic)
  • Expertise with machine-learning methods, and statistical analyses using R or python
  • Experience with assembly methods is highly desirable
  • Experience with long-read technologies is highly desirable
  • Understanding of cancer cell biology or immunology is highly desirable
  • Evidence of scientific accomplishment via peer-reviewed publications is required
  • Highly motivated with excellent organizational, problem-solving and communication skills (verbal and written)

Additional Information:

How to Apply

Interested and qualified applicants should send (1) a cover letter describing previous work, career goals, and proposed start date, (2) CV, and (3) contact information for three referees.

 

About the University of Calgary

The University of Calgary is ranked fifth among Canada’s top research universities, and the youngest institution to reach the top five. Located in the nation’s most enterprising city, the university has a clear strategic direction where innovative teaching and groundbreaking research go hand in hand, and where we fully engage the communities we both serve and lead. The strategy, called Eyes High, is inspired by our Gaelic motto which translates to ‘I will lift up my eyes’.

About Calgary Named a cultural capital of Canada and one of the best places to live in the world, Calgary is a city of leaders – in business, community, philanthropy and volunteerism. Calgarians enjoy more days of sunshine per year than any other major Canadian city, an hour’s drive to the majestic Rocky Mountains, and the most extensive urban pathway and bikeway network in North America. All qualified candidates are encouraged to apply; however, Canadians and permanent residents will be given priority. The University of Calgary respects, appreciates, and encourages diversity.

Keywords:

Analysis

Assembly

Cancer

Computational

Genomics

Immunotherapy

Phylogenetics

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