13 days ago
Institution/Company:

Vaccine and Infectious Disease Organization (VIDO), Univeristy of Saskatchewan

Location:

Saskatoon

, Saskatchewan

 Canada

Job Type:

Postdoctoral

Degree Level Required:

PhD

Apply now
Description:

The Vaccine and Infectious Disease Organization (VIDO), Canada’s Centre for Pandemic Research, is a world leader in infectious disease research and vaccine development for humans and animals. Located at the University of Saskatchewan in Saskatoon, Canada, VIDO is home to one of the largest and most advanced containment level 3 facilities in the world. To strengthen the preparedness for emerging infectious diseases we are currently expanding our infrastructure to include containment level 4 capacity, a GMP vaccine manufacturing facility, and a new animal housing facility. Our vision includes having the capacity to study any emerging disease in any animal model embracing a One Health approach to prevent emerging and re-emerging infectious diseases in humans and animals.

Responsibilities:

Position Summary
Dr. Gordon Broderick, Principal Investigator, Mathematical Immunology and Immunodynamics (MII) Group is seeking a highly motivated individual with an interest in the mathematical modelling of biological regulatory network dynamics at the molecular and cellular levels. Research components include network assembly from prior knowledge (text and schema) and available experimental data, large-scale combinatorial optimization for parameter estimation and attractor mapping, as well as multi-scale dynamic simulation, all with an emphasis on massively distributed computing and the design of quantum algorithms. Among the many applications, these simulation models will initially be used to understand immune regulatory programs acquired in chronic obstructive pulmonary disease (COPD) and conferring increased susceptibility to infection, as well as anomalies in immune maturation in neonates and young children leading to ineffective response to childhood vaccines. Ongoing work will also involve the investigation of self-sustaining regulatory programs supporting persistent illness in Long-COVID.

As part of a larger computational and systems biology initiative at VIDO, the group’s research is focused on the development of analytical approaches rooted in information theory, and formal dynamic systems theory, and their use in deciphering the complex regulatory programming that coordinates the joint immune, nervous and endocrine system responses to infection. Large-scale computer simulations of these regulatory dynamics are then used to identify novel vaccine formulations as well as design strategies to broaden response in the general population, better target vulnerable populations and improve outcomes from infection.

VIDO offers a unique transdisciplinary research environment at the intersection of the basic life sciences and physical sciences with the MII Group focused increasingly on the use of quantum algorithms through its membership in the University of Saskatchewan’s Centre for Quantum Topology and Its Applications (quanTA) with privileged access to IBM’s Quantum System One.

 

 

Qualifications:

Profile
We are looking for a highly motivated and enthusiastic scientist with the following competencies and experience:

Essential experience and skills:
•PhD (completed in the past three years) in engineering, mathematics, computer science, applied physics or related discipline.
•Proficiency in numerical optimization techniques and related solvers
•Proficiency in Python programming and related rapid prototyping environments for the design of novel algorithms and their validation using custom code.
•Strong interest in the modeling of network dynamics.

Desirable experience and skills:
•Strong background of first principles differential equation models, with an emphasis on discrete logic formulations.
•Strong background in high-performance distributed computing
•Strong interest in quantum computing
•Background in dynamic systems theory including basic regulatory control principles.

 

Additional Information:

Status: 2-year term, with the possibility of extension

Employment Group: Post-Doctoral Fellows – PSAC

Full Time Equivalent (FTE): 1.0

Salary Information: The starting salary will follow the university standard for a post-doctoral researcher and will be commensurate with experience.

The successful applicant will be required to provide the following current verification(s) where ‘Yes’ is indicated below. Further information is available at: https://careers.usask.ca/tips-for-applying.php#Howtoapplyforaposition

Facility Access Screening including Criminal Record Check: Yes

Driver’s License and Abstract Check: Not Applicable

Education/Credential Verification: Yes

Vulnerable Sector Check: Not Applicable

Interested candidates are asked to submit their application in one single application document (pdf file) including a statement of research interest, complete curriculum vitae (CV), and contact information of three references.

Apply Now
Review of applications will begin immediately; however, applications will be accepted and evaluated until August 31st, 2024. We thank all applicants for their interest; only those candidates selected for an interview will be contacted.
Apply online at: https://vido.applytojobs.ca/research/30635

Living in Saskatoon
•One of the lowest costs of living among major cities in Canada (https://www.saskatoon.ca/community-culture-heritage/new-saskatoon/life-saskatoon)
•One of the sunniest places in Canada (https://www.saskatoon.ca/community-culture-heritage/new-saskatoon/life-saskatoon)
•A leading centre of culture and learning, Saskatoon is also one of the most socially engaged and most literate cities in Canada (https://admissions.usask.ca/campus-life/housing.php#LivinginSaskatoon)

For more information visit: Discover Saskatoon
For more information visit: vido.org

Note: The University believes equity, diversity, and inclusion strengthen the community and enhance excellence, innovation and creativity. We are dedicated to recruiting individuals who will enrich our work and learning environments. All qualified candidates are encouraged to apply; however, in accordance with Canadian immigration requirements, Canadian citizens and permanent residents will be given priority. We are committed to providing accommodations to those with a disability or medical necessity. If you require an accommodation in order to participate in the recruitment process, please notify us and we will work together on the accommodation request. The University of Saskatchewan’s main campus is situated on Treaty 6 Territory and the Homeland of the Métis. We pay our respects to the First Nations and Métis ancestors of this place and reaffirm our relationship with one another. Together, we are uplifting Indigenization to a place of prominence at the University of Saskatchewan.

Keywords:

engineering

mathematics

computer science

applied physics

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