Jobs

POSTDOCTORAL FELLOWSHIP POSTING — CHUM RESEARCH CENTRE

Liquid biopsies are ushering in a new era in cancer diagnostics, making it possible to detect tumors from a simple blood draw.

In this context, our laboratory is developing a next-generation molecular technology to improve the sensitivity and specificity of circulating tumor DNA (ctDNA) detection.

This project offers a unique opportunity to contribute to a tangible biomedical advance at the intersection of technological innovation and precision medicine. This research program is fully funded and aims to change clinical practice in oncology.

The postdoctoral fellow will lead the development and validation of a novel experimental method with high clinical potential for liquid biopsies. The research program is fully funded and targets direct clinical impact.

The goal is to create a robust, reproducible, and sensitive technology capable of identifying cancer-associated genetic alterations — with the ambition of transforming patient care.

Candidate Profile

We are seeking an outstanding postdoctoral researcher driven by the ambition to transform clinical practice in oncology. Ideal profile:

• PhD. in molecular biology, genomics, biomedical engineering, or a related field;
• Strong publication record demonstrating the ability to lead high-caliber research projects;
• Experience in bioinformatics and sequencing data analysis (a major asset);
• Autonomy, experimental rigor, critical thinking, and the ability to work in a multidisciplinary team.

About the Laboratory

Professor Alexandre Pellan Cheng is an Associate Professor at ÉTS, a researcher at the CHUM Research Centre, and a member of the Open Innovation Laboratory (LIO). He obtained his Ph.D. in biomedical engineering from Cornell University and completed his postdoctoral training at the New York Genome Center.

The laboratory works in close collaboration with Dr. Antoine Desilets, a clinician-scientist at the CRCHUM with expertise in molecular oncology. A former Fellow at Memorial Sloan Kettering Cancer Center (MSKCC), Dr. Desilets leads a program of investigator-initiated trials (IITs), providing a true bench-to-bedside pathway for all projects in the group.

Details and Work Environment

• Compensation: Competitive postdoctoral salary (commensurate with experience)
• Location: CHUM Research Centre (CRCHUM), Montréal
• Affiliation: Postdoctoral fellowship, École de technologie supérieure (ÉTS) / CHUM Research Centre

Contact

alexandre.pellan-cheng@etsmtl.ca

https://pellanchenglab.github.io/

ANNONCE DE STAGE POSTDOCTORAL AU CENTRE DE RECHERCHE DU CHUM

Les biopsies liquides ouvrent une nouvelle ère dans le diagnostic du cancer, en rendant possible la détection de tumeurs à partir d’un simple prélèvement sanguin. Dans ce contexte, notre laboratoire développe une technologie moléculaire de nouvelle génération pour améliorer la sensibilité et la spécificité de la détection de l’ADN tumoral circulant (ctDNA). Ce projet offre l’opportunité unique de contribuer à une avancée biomédicale concrète, au croisement de l’innovation technologique et de la médecine de précision. Ce programme de recherche est entièrement financé et s’inscrit dans une démarche visant à changer la pratique clinique en oncologie.

Le/la stagiaire postdoctoral.e dirigera le développement et la validation d’une nouvelle méthode expérimentale à fort potentiel clinique pour les biopsies liquides. Le programme de recherche est entièrement financé et vise un impact clinique direct.

L’objectif est de créer une technologie robuste, reproductible et sensible, capable d’identifier des altérations génétiques associées au cancer — avec l’ambition de transformer la prise en charge clinique des patients.

Profil recherché

Nous recherchons un.e chercheur.e postdoctoral.e d’excellence, animé.e par l’ambition de transformer la pratique clinique en oncologie. Profil recherché :

• Doctorat (Ph.D.) en biologie moléculaire, génomique, génie biomédical ou domaine connexe ;
• Dossier de publications solide démontrant une capacité à mener des projets de recherche de haut calibre ;
• Expérience en bioinformatique et analyse de données de séquençage (un atout majeur) ;
• Autonomie, rigueur expérimentale, esprit critique et capacité à travailler en équipe multidisciplinaire.

À propos du laboratoire

Le professeur Alexandre Pellan Cheng est professeur agrégé à l’ÉTS, chercheur au Centre de recherche du CHUM, et membre du Laboratoire d’innovation ouverte (le LIO). Il a obtenu son doctorat en génie biomédical de Cornell University et a effectué ses recherches postdoctorales au New York Genome Center. Le laboratoire travaille en étroite collaboration avec le Dr Antoine Desilets, clinicien-chercheur au CRCHUM spécialisé en oncologie moléculaire. Ancien Fellow au Memorial Sloan Kettering Cancer Center (MSKCC), le Dr Desilets dirige un programme d’essais cliniques initiés par l’investigateur (IITs), offrant ainsi un véritable continuum du laboratoire au chevet du patient pour l’ensemble des projets du groupe.

Détails et environnement de travail

• Rémunération : Salaire postdoctoral compétitif (selon l’expérience)
• Lieu : Centre de recherche du CHUM (CRCHUM), Montréal
• Affiliation : Stage postdoctoral, École de technologie supérieure (ÉTS) / Centre de recherche du CHUM

Contact

alexandre.pellan-cheng@etsmtl.ca

https://www.desiletschenglabs.com/

Postdoctoral Fellow in Bioinformatics

Modernizing Medical Microbiology Sequencing-Based Diagnostics

We are seeking a postdoctoral fellow to join a multidisciplinary research program focused on modernizing next generation sequencing-based diagnostics in infectious diseases. The project sits at the interface of clinical microbiology and translational genomics, with the objective of developing and implementing tools with tangible clinical applications.

The research program is structured around three main axes: (1) cell-free DNA metagenomic next-generation sequencing (cfDNA mNGS) from clinical samples, (2) antimicrobial resistance (AMR) prediction and genotypic drug susceptibility testing (DST) pipelines, and (3) molecular epidemiology and comparative bacterial genomics.

The position is based at the Centre hospitalier de l’Université de Montréal and the Centre de recherche du CHUM, within a highly collaborative environment integrating clinical services, reference laboratories, and public health partners.

Applicants should submit their Curriculum vitae and a brief statement of interest to simon.grandjean.lapierre@umontreal.ca and alexandre.pellan-cheng@etsmtl.ca. Applications will be reviewed on a rolling basis.

We are committed to equity, diversity, and inclusion and encourage applications from individuals of all backgrounds.

Postdoctorat en bioinformatique

Modernisation des outils diagnostics basés sur le séquençage en microbiologie médicale

Nous sommes à la recherche d’un·e stagiaire postdoctoral·e pour se joindre à un programme de recherche multidisciplinaire visant à moderniser les outils diagnostics basés sur le séquençage de nouvelle génération en maladies infectieuses. Le projet se situe à l’interface entre la microbiologie clinique et la génomique translationnelle, avec pour objectif de développer et de mettre en œuvre des outils ayant des applications cliniques concrètes.

Le programme de recherche est structuré autour de trois axes principaux : (1) le séquençage métagénomique de l’ADN libre circulant (cfDNA mNGS) à partir d’échantillons cliniques, (2) la prédiction de la résistance aux antimicrobiens (RAM) et les pipelines de tests de sensibilité génotypiques (DST), et (3) l’épidémiologie moléculaire et la génomique bactérienne comparative.

Le poste est basé au Centre hospitalier de l’Université de Montréal et au Centre de recherche du CHUM, au sein d’un environnement hautement collaboratif intégrant services cliniques, laboratoires de référence et partenaires de santé publique.

Les candidat·e·s doivent soumettre leur curriculum vitae et une brève lettre d’intérêt à  simon.grandjean.lapierre@umontreal.ca et alexandre.pellan-cheng@etsmtl.ca. Les candidatures seront évaluées au fur et à mesure de leur réception.

Nous sommes engagés envers l’équité, la diversité et l’inclusion et encourageons les candidatures de personnes issues de tous les horizons.

The Edwin S. H. Leong Centre for Healthy Aging (ELCHA) is seeking a highly motivated Postdoctoral Research Fellow for the Canadian Microbiome Mapping Initiative (CMMI).  This will be a 100% FTE (full-time) position for a one-year term with the possibility of renewal. Work will be performed on-site at the Edwin S. H. Leong Centre for Healthy Aging at the UBC Vancouver campus with the possibility of a hybrid work agreement.

The salary range for this position is $65,000 – $75,000 per annum, plus benefits.

The primary goal of the CMMI is to develop an integrated multi ‘omics platform to investigate the biological mechanisms and pathways by which the microbiome influences health and disease. This will include investigations into healthy aging as well as validation of the platform in clinical contexts, beginning with Parkinson’s disease. The successful candidate will serve as a data manager to liaise between the project’s different data generating and database development teams and facilitate the integration, analysis, and interpretation of datasets. This role is part of a broader vision to spearhead data integration and analysis of a growing multi-‘omic dataset designed to study healthy aging, Parkinson’s Disease, and other age-related conditions.

The Yang Zhang Lab at the National University of Singapore (NUS) is recruiting two postdoctoral fellows in artificial intelligence and computational biology. The lab is jointly based in the School of Computing, the Yong Loo Lin School of Medicine, and the Cancer Science Institute of Singapore, working at the interface of computer science, structural biology, and biomedical research.

The positions focus on developing next-generation AI methods for biomolecular modeling and AI-driven drug discovery, including protein/RNA folding, structure prediction, and sequence design. The research is method-driven, emphasizing original algorithm/model development (foundation-model architectures integrating sequence, structure, and physical information) rather than applying existing pipelines to standard benchmarks.

Fellows will work in a computationally intensive environment with access to large-scale HPC (hybrid NVIDIA GPU/CPU clusters) and are expected to lead projects from conception through large-scale training and rigorous evaluation.

A 2-year (renewable) full-time postdoctoral fellowship is available in the laboratory of Prof. Alain Dabdoub. The position focuses on decoding the molecular landscape of the human inner ear during development and regeneration and translating these findings to advance therapeutic strategies. Our research investigates mechanisms that regulate auditory and vestibular homeostasis, the regeneration of sensory hair cells, stria vascularis, and auditory neurons as well as the implications for therapies and understanding disorders associated with aging, hearing loss, and balance dysfunction. Our projects combine state of-the-art computational tools and cutting-edge biological experiments.