Position Title: Bioinformatics/Biologist

Department: Pathobiology
Description of the Area/Topic of Research:

The Ricker lab at the University of Guelph is currently recruiting 1 PhD student and 1 post-doctoral fellow or research associate, in collaboration with Dr. Hany Anany (AAFC), for projects recently funded through the Canadian Poultry Research Council (CPRC) and Agriculture-AgriFood Canada (AAFC).

Antimicrobial resistance (AMR) is one of the largest human health concerns of this generation, as the continued emergence of resistance threatens to interfere with our ability to treat and prevent human infectious diseases. Combating AMR requires a One Health approach, combining efforts at limiting resistance emergence and spread within human, animal and environmental reservoirs.

We are currently seeking two candidates (a PhD student and a postdoctoral fellow) for a 4-year project investigating the use of phage to control Salmonella within the poultry industry. The successful candidates will meet or exceed the minimum academic requirements for entry to a PhD program, have a relevant publication record appropriate to their current career stage, and have previous experience working with phage. An interest in the combination of microbiology techniques and bioinformatic approaches is essential. Experience in metagenomics, phage biology, phage-host interactions, designing and performing bacterial challenge studies and/or viromics are all considered strong assets. Work will be performed at both the University of Guelph and AAFC in Guelph under joint supervision of Drs. Ricker and Anany.

Funding for this project is pending final confirmation and a start date of May 1, 2024 is preferred but is negotiable.

Description of Lab/Group/Area: Dr Ricker is an early career researcher recruited to the University of Guelph through the Food from Thought program for her expertise in microbial community analysis and antimicrobial resistance (AMR) in agriculture.  Her developing research program focuses on AMR prevalence in bacterial communities, horizontal gene transfer mechanisms, promotion of healthy gut microbial communities, and the impact of mitigation strategies on the emergence, persistence, and dissemination of AMR and pathogens in a One Health framework.

Dr. Anany is a Bacteriophage Research Scientist at the Guelph Research and Development Center (GRDC), Agriculture and Agri-Food Canada. In addition, he serves as an Adjunct Professor at the Food Science Department, University of Guelph. His research program focuses on understanding phage biology and its interaction with bacterial hosts for taxonomical and application purposes throughout the food supply chain. Dr. Anany’s research program also extends to exploring the composition and dynamics of the phageome /virome throughout the food supply chain, aiming to deepen our understanding of these complex viral communities and their role in food safety.

Description

An exciting postdoctoral research opportunity is currently available in our dynamic research group at the intersection of single-cell genomics and machine learning. The Mer lab (https://merlab.github.io/) at the University of Ottawa, Canada in collaboration with Megha Chandrashekhar (Canadian Nuclear Laboratories) are seeking to recruit a postdoctoral fellow. You will lead a groundbreaking project to explore the effect of radiation on primary and hematopoietic stem cells. The selected candidate will become an integral part of our interdisciplinary team, specializing in conducting comparative analyses and implementing cutting-edge computational algorithms for the analysis of multi-omics single-cell sequencing datasets (including scRNA-seq, scAb-seq, and scATAC-seq). 

Why Join Us: 

• Opportunity to take lead and work on groundbreaking projects at the forefront of single-cell genomics and radiation biology. 
• Collaboration with esteemed university centers such as the Ottawa Institute of Systems Biology (OISB), the Ottawa Hospital Research Institute and Canadian Nuclear Laboratories 
• Strong support for independent research directions and career development plans. 
• Mentorship opportunities and collaboration with graduate students and research assistants. 

The Computational Biology & Gene Regulation group led by Anthony Mathelier at the NCMM, a part of the Nordic EMBL Partnership for Molecular Medicine, is seeking a highly motivated Researcher or Postdoctoral Fellow for a two-year position, starting as soon as possible in 2024. The selected candidate will play a pivotal role in a collaborative project spanning internationally renowned groups, namely those of Drs. Anshul Kundaje at Stanford University, USA, Wyeth Wasserman at the University of British Columbia, Canada, and Anthony Mathelier, NCMM, Norway. The position will be based in Norway. More information about the group can be found at https://mathelierlab.com/.

Join us to not only advance your career but also contribute to meaningful scientific discoveries and resources in the world of computational biology and gene regulation.

Position Description

The selected candidate will contribute to a cutting-edge project aimed at enhancing and expanding computational resources to decipher transcription factor (TF) – DNA interactions. The focus will be on the enhancement of the JASPAR (https://jaspar.elixir.no) and UniBind (https://unibind.uio.no) databases, which ELIXIR Norway recognizes as a Norwegian bioinformatics service. Specifically, the candidate will utilize advanced deep learning techniques to provide refined models and data crucial for the analysis of disease mutations affecting gene expression.

The candidate can refer to the following publications, which can be discussed during the interview: https://doi.org/10.1093/nar/gkad1059, https://doi.org/10.1186/s12864-021-07760-6, https://doi.org/10.1038/s41588-021-00782-6.

Postdoctoral Positions in Etienne Caron Lab at Department of Immunobiology, Yale School of Medicine. The Caron Lab seeks postdoctoral applicants with a passion for innovation in mass spectrometry-based immunopeptidomics research. The overarching goal of the Caron Lab is to develop and apply mass spectrometry-based methods and systems immunology approaches to understand the generation, composition and dynamics of both the self and nonself immunopeptidome, as well as its interaction with T cells, with the ultimate goal of innovating treatments and preventive strategies for a broad range of immune-related diseases.

Opportunities and Benefits. Postdocs will have the opportunity to gain expertise in mass spectrometry, systems immunology, spatial immunopeptidomics, T-cell epitope discovery, immunology, and vaccine design. The selected candidates will also have the opportunity to become active players within several Yale Centers, including the Yale Center for Immuno-Oncology (YCIO), Center for Infection and Immunity (CII), and Center for Systems and Engineering and Immunology (CSEI). Strong support will be given to purse independent directions. Postdoc compensation and benefits will be according to Yale policies. More information about salaries and other resources can be found at https://postdocs.yale.edu/.