Jobs

The Latner Thoracic Surgery Laboratories at the University Health Network in Toronto is inviting applications for a Post-Doctoral Fellow. The successful candidate will lead a project defining genomic and transcriptomic features in esophageal adenocarcinoma. Our samples include laser capture microdissected whole genome and RNA-seq samples from pre-treatment primary tumour biopsies, post-treatment surgical resections, and metastatic biopsies. We have current sequenced approximate 40 whole genomes with matched germline data and 50 whole transcriptomes with a goal to reach NN samples. The candidate will be part of an integrative group including members from a comprehensive clinical program in esophageal cancer, experts in esophageal adenocarcinoma patient derived organoid models, cancer biologists, and bioinformaticians. The successful candidate will be supervised by a clinician-scientist PI and a bioinformatics/genomics PI.

Successful candidates will be recent PhD graduates who are interested in making fundamental discoveries in tumor evolution and immune response that can lead to translational impact in aggressive and largely incurable cancers.

Research approaches in our team include computational analyses of tumor multi-omic profiles at bulk and single cell level, with spatial and temporal resolution within patient samples. We are interested in how tumor cells cooperate with non-neoplastic cells of the microenvironment to respond to selective pressures in general, and in particular to standard therapy regimes. The focus of the candidate will be on establishing methods to integrate long-read sequencing data into our current workflows for genome and transcriptome analyses. Key goals include identification of novel biomarkers and targets for therapy that can be further pursued within a fully operational preclinical pipeline toward clinical translation.

The lab is part of a multi-disciplinary team of cancer researchers filled with passionate and determined individuals who will provide the successful candidate with a stimulating and conducive environment to participate and grow as a scientist. The research is conducted at the University of Calgary, in close collaboration with local and international scientists and clinicians, and thus will also provide the successful candidate with opportunities to learn from a large network of talented professionals.

The Kridel lab is seeking a talented postdoctoral fellow to lead ongoing efforts to enhance our understanding of lymphoma pathogenesis by leveraging large datasets. The research will focus on either of the following topics: (i) dissection of immune correlates underlying both common and rare lymphoma types using single cell sequencing; (ii) development of liquid biopsy-based biomarkers for the accurate classification and monitoring of lymphoma. The post-doctoral fellow will design and carry out experiments to address key questions in the above topics and lead the writing of scientific manuscripts. The successful candidate will be embedded in a rich scientific environment that provides ample opportunities for development of technical, as well as leadership skills. Highly motivated individuals with a desire to make an impact in the field of cancer genomics are encouraged to apply.