Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Job Reference No. ABC_P00183_HSA154648_Software Development_2024_01_16

Summary

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.
The Assistant Bioinformatics Coordinator provides supervisory and technical support to the Bioinformatics group of the Genome Sequence Centre (GSC). Ensures that the day-to-day activities of a large scale, high throughput facility meet research, data analysis throughput and software development objectives.

Position: Bioinformatician
Location: MaRS Centre, Toronto
Department: Diagnostic Development
Reports To: Co-Director, Diagnostic Development and Principal Research Scientist
Salary: Commensurate with level of experience
Hours: 35 hours/week
Job Type: Hybrid
Status: Full-time, Temporary (2-year contract)

The Ontario Institute for Cancer Research (OICR) is seeking a bioinformatician who possess relevant training to join the Diagnostic Development program. The program aims to develop personalized medicine approaches that maximize the chances of positive outcomes for those experiencing cancer. Our team includes internationally recognized experts in biomarker discovery and validation, and actively works with diagnostics industry and biotech companies. We are generating multiple independent genomic analyses including next-generation genomic and transcriptome sequencing and spatial proteomic data. Working under the direction of the senior staff you will have the opportunity to work with the datasets from clinical trials and to address problems that have direct impact on clinical needs and patient care.

This position is temporary, full-time for two-years with the possibility of an extension.

OICR is Ontario’s cancer research institute. We bring together people from across the province and around the world to improve the lives of everyone affected by cancer. We take on the biggest challenges in cancer research and deliver real-world solutions to find cancer earlier and treat it more effectively. We are committed to helping people living with cancer, as well as future generations, live longer and healthier lives.

Launched in December 2005, OICR is an independent institute funded by the Government of Ontario through the Ministry of Colleges and Universities.

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Job Reference No. CB_P01066_Software Development_HSA154623_2023_10_24

Job Summary

In accordance with the Mission, Vision and Values, and strategic directions of PHSA, safety, including both patient and employee safety, is a priority and a responsibility shared by everyone at PHSA. As such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

The Computational Biologist participates in developing, improving and maintaining bioinformatics tools for high-throughput processing pipelines. The Computational Biologist specifies, implements, tests and maintains bioinformatics computer applications and systems, and participates in the code walk-throughs and design and review of bioinformatics software solutions. The Computational Biologist will also assist in the packaging and distribution of developed tools and analysis results to the scientific community, and will contribute to the preparation of scientific publications.

Are you an NLP engineer with a passion for biomedicine? Are you frustrated by the sclerotic structures and misaligned incentives of the industry?  Do you have a track record of using machine learning to solve complex problems in the field of biomedicine? If so, come work with us at Weave. Weave is building a generative AI platform that will revolutionize how life science companies collaborate.

We are seeking a talented NLP engineer to join our team and help us push the boundaries of what is possible with machine learning in the field of biomedicine. As an NLP engineer, you will be responsible for designing, implementing, and evaluating state-of-the-art NLP models and solutions that address real-world challenges in the biomedical domain. You will work closely with our team of researchers and developers to build and deploy NLP systems that extract valuable insights from biomedical data, including electronic health records, scientific literature, and clinical notes.

To be successful in this role, you should be familiar to biomedical terminology, and a deep understanding of NLP techniques and machine learning algorithms. You should also have experience working with large datasets and be superb at coding in Python.

If you are a highly motivated and talented NLP engineer with a passion for biomedicine, please reach out – we’d love to work together.  Email us at join@weave.bio.

We are recruiting a software engineer (full stack developer) to join our multidisciplinary team. The incumbent will be responsible for the implementation of computational systems surrounding a novel diagnostic workflow that integrates genomic data produced in real-time. Under the supervision of the research director and in collaboration with local medical, laboratory and IT staff, the candidate will be responsible for developing “full stack” IT and software solutions for the processing, management and delivery of clinical reports in real-time.

About the team

Dr Martin Smith’s laboratory (www.therealsmithlab.com) harmonizes genomic technologies and artificial intelligence to realize the enormous potential of nanopore sequencing in precision medicine. Our research group specializes in the development and implementation of precise, practical and economical applications for nanopore sequencing in clinical, academic and commercial environments. In particular, the laboratory is currently focusing on the implementation of a new computational solution for rapid, precise and cost-effective diagnosis of pediatric leukemias based on real-time gene expression profiling (transcriptomics).

The Smith lab is part of the Cancer and Immune Disorders Research Axis of the CHU Sainte-Justine Research Centre and is affiliated with the bioinformatics program at the University of Montreal.

Work environment

The Sainte-Justine University Hospital Center (CHU) is the largest mother-child center in Canada and one of the four largest pediatric centers in America. Its 5,000 employees and 500 doctors, dentists and pharmacists work in a highly innovative and respectful environment, placing patients and their family at the heart of medical practice. Through its association with the University of Montreal, CHU Sainte-Justine is the largest pediatric training center in Quebec and a leader in Canada, welcoming over 4,000 students and interns each year.

The CHU Sainte-Justine Research Center hosts more than 1200 scientists, including over 210 principle investigators, 110 clinicians and more than 450 graduate and postdoctoral students. Driven by a vision of research excellence, the center strives to ensure that Quebec remains as world leader in healthcare and biomedical research benefiting mothers, children, and adolescents. The Centre’s mission is focused on advancing scientific knowledge while delivering faster and less invasive strategies for the prevention, diagnosis, prognosis, treatment, and long-term follow-up of patients–from the conception until adulthood.

Employment conditions

CHU Sainte-Justine Research Center Employees Union (SECR)
Reporting to: Dr Martin Smith
Type: Regular, full-time (35h/week)
Start date: Immediately
Duration of mandate: 2 years