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27 days ago

Research Associate

Ontario Institute for Cancer Research -

Position: Bioinformatician I
Location: MaRS Centre, Toronto
Department: Drug Discovery Program
Reports To: Scientific Advisor
Salary: Commensurate with level of experience; total compensation includes a competitive benefits plan (Sun Life), plus a defined benefit pension plan (HOOPP)
Hours: 35 hours/week
Job Type: Hybrid
Status: Full-Time, Temporary (1-year contract with possible conversion to permanent position)

 

The Ontario Institute for Cancer Research (OICR) is seeking a Bioinformatician who possesses the relevant training to join the Drug Discovery (DD) Program. The program aims to help efficiently translate discoveries made in Ontario’s labs into novel oncology therapies, spanning the entire drug discovery process from target identification and validation to clinical candidate selection.  The DD Program is collaborating with OICR’s Adaptive Oncology (AO) to develop computational tools to identify and prioritize biological targets and biomarkers. The AO Program seeks to develop knowledge and approaches to monitor cancer over time and in response to treatment, to enable precise and proactive clinical management.

 

This position is temporary, full-time for one-year, with the possibility of conversion to a permanent position.

 

The successful candidate will work closely with data scientists and biologists from OICR’s Adaptive Oncology and Drug Discovery programs to co-develop novel algorithms/methods and pipelines for target/biomarker discovery. This is an exciting opportunity to learn about the latest developments in drug discovery and the use of various bioinformatic and machine learning approaches in computational biology, while contributing to the development of new treatments for cancer.

 

While most work is completed remotely, there will be occasional onsite team meetings or events, where attendance is expected.

About OICR

OICR is Ontario’s cancer research institute. We bring together people from across the province and around the world to improve the lives of everyone affected by cancer. We take on the biggest challenges in cancer research and deliver real-world solutions to find cancer earlier and treat it more effectively. We are committed to helping people living with cancer, as well as future generations, live longer and healthier lives.

Launched in December 2005, OICR is an independent institute funded by the Government of Ontario through the Ministry of Colleges and Universities.

 

For more information about OICR, please visit the website at www.oicr.on.ca.

To learn more about working at OICR, visit our career page.

41 days ago

Research Associate

University of British Columbia -

The Michael Smith Laboratories at the University of British Columbia in Vancouver, Canada, invites applications for a Research Associate position in Next-Generation RNA Therapeutics to join a dynamic and multidisciplinary team under the co-supervision of Dr. Anna Blakney and Dr. Jay Kizhakkedathu. The successful candidate will work on a project to develop new polymeric strategies for delivery of RNA. The Blakney Lab at UBC (blakneylab.msl.ubc.ca) develops next-generation RNA vaccines and therapies based on self-amplifying RNA and using interdisciplinary approaches including bioengineering, immunology, molecular biology and bioinformatics. The Kizhakkedathu lab (https://cbr.ubc.ca/our-people/investigators/jayachandran-kizhakkedathu/) develops novel polymers and biomaterials as therapeutics and devices.

Project: RNA medicines have gained considerable momentum in the past few years with the approval of Onpattro and the COVID-19 messenger RNA vaccines. While lipid nanoparticles (LNPs) are the state-of-the-art delivery system for RNA, we recently discovered that polymeric nanoparticles are less inflammatory and induce higher protein expression than LNPs. For this project, we are keen to explore the polymer design space for RNA delivery for a variety of applications. The PDF will work with the Blakney and Kizhakkedathu labs to design and synthesize novel polymers, and test them for RNA delivery and immunogenicity in vivo in preclinical models. We anticipate that polymers are a clinically translatable delivery system for RNA therapeutics.

65 days ago

Research Associate

OICR -

Position: Bioinformatician II

Location: MaRS Centre, Toronto

Department: Genome Sequence Informatics

Reports To: Manager, Genome Interpretation

Salary: Commensurate with level of experience

Hours: 35 hours/week

Job Type: Hybrid Status: Full-Time, Permanent

The Ontario Institute for Cancer Research (OICR) Genomics Program is seeking a Bioinformatician for the Cancer Genome Interpretation group, part of Genome Sequence Informatics (GSI) and OICR-PM Joint Genomics Program (https://genomics.oicr.on.ca/).

The Cancer Genome Interpretation (CGI) group is a team of bioinformaticians developing analytic approaches for reporting clinical genomic data. The ideal candidate will have proven skills in both genome biology and bioinformatic analysis. The Bioinformatician will collate sequencing results from clinical cases, identify and provide details on clinically actionable variation, and draft clinical reports for review by a board-certified Geneticist. In addition, the Bioinformatician will develop and validate new cancer genome analysis approaches to incorporate into our suite of CAP- and IQMH- clinically accredited assays.

OICR is Ontario’s cancer research institute. We bring together people from across the province and around the world to improve the lives of everyone affected by cancer. We take on the biggest challenges in cancer research and deliver real-world solutions to find cancer earlier and treat it more effectively. We are committed to helping people living with cancer, as well as future generations, live longer and healthier lives.

Launched in December 2005, OICR is an independent institute funded by the Government of Ontario through the Ministry of Colleges and Universities.

65 days ago

Research Associate

OICR -

Position: Bioinformatician I

Location: MaRS Centre, Toronto

Department: Drug Discovery Program

Reports To: Scientific Advisor

Salary: Commensurate with level of experience

Hours: 35 hours/week

Job Type: Hybrid Status: Full-Time, Temporary (1-year contract with possible conversion to permanent position)

 

The Ontario Institute for Cancer Research (OICR) is seeking a bioinformatician who possesses the relevant training to join the Drug Discovery (DD) Program. The program aims to help efficiently translate discoveries made in Ontario’s labs into novel oncology therapies, spanning the entire drug discovery process from target identification and validation to clinical candidate selection. The DD Program is collaborating with OICR’s Adaptive Oncology (AO) to develop computational tools to identify and prioritize biological targets and biomarkers. The AO Program seeks to develop knowledge and approaches to monitor cancer over time and in response to treatment, to enable precise and proactive clinical management.

This position is temporary, full-time for one-year, with the possibility of conversion to a permanent position.

The successful candidate will work closely with data scientists and biologists from OICR’s Adaptive Oncology and Drug Discovery programs to co-develop novel algorithms/methods and pipelines for target/biomarker discovery. This is an exciting opportunity to learn about the latest developments in drug discovery and the use of various bioinformatic and machine learning approaches in computational biology, while contributing to the development of new treatments for cancer.

While most work is completed remotely, occasionally onsite team meetings or events, where attendance is expected.

OICR is Ontario’s cancer research institute. We bring together people from across the province and around the world to improve the lives of everyone affected by cancer. We take on the biggest challenges in cancer research and deliver real-world solutions to find cancer earlier and treat it more effectively. We are committed to helping people living with cancer, as well as future generations, live longer and healthier lives.

Launched in December 2005, OICR is an independent institute funded by the Government of Ontario through the Ministry of Colleges and Universities

125 days ago

Research Associate

University of British Columbia -

The Michael Smith Laboratories at the University of British Columbia in Vancouver invites applications for a Research Associate position in Computational Biology to join the laboratory of Dr. Marco Marra. The successful candidate will support a dynamic interdisciplinary team of scientists and trainees in the area of cancer genomics and precision medicine.