We are seeking an outstanding and highly motivated PhD student in Computational Biology or Bioinformatics to join the Translational and Integrative Pathobiology Lab (LCTIP‑Lab) in Québec City. This position offers a unique opportunity to work at the forefront of spatial omics, tumor microenvironment (TME) biology, and multimodal data integration, under the co‑supervision of Dr Philippe Joubert and Dr Fabien Lamaze.

The PhD project focuses on Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH)—a rare and poorly understood precursor lesion that can progress to pulmonary carcinoid tumors. This understudied disease context provides a rare opportunity to make first‑in‑field discoveries with strong translational relevance.

By leveraging spatial transcriptomics, deep genomic profiling, and TME‑focused analyses, the successful candidate will investigate clonal evolution and molecular mechanisms driving disease progression at high spatial resolution. The project is designed to generate impactful insights into lung cancer biology while providing rigorous training in advanced computational and analytical methods.

Research Environment & Resources

The successful candidate will work with state‑of‑the‑art spatial and single‑cell platforms, including:

• Visium HD
• Xenium
• PhenoCycler‑Fusion
• CyTOF

These technologies are rarely available together within a single PhD project. The lab provides access to deeply annotated clinical, histological, and genomic datasets, and fosters a highly collaborative environment bridging pathology, genomics, computational biology, and machine learning.

Strong mentorship is provided in:

• Computational and statistical methods
• Cancer and TME biology
• Scientific writing, presentations, and academic career development

About 5 Prime:

5Prime Sciences uses human genetics to accelerate drug development. Over the past four years, we’ve helped pharmaceutical, biotech, and venture partners accelerate and de-risk pipelines—enabling some to move from target to Phase 2 in two years. Our mission is to deliver medicines to patients in need.

We are a premier partnership business, working side-by-side with pharma, biotech, and venture groups as trusted specialists. Most new work comes through referrals—approximately 80% of revenue is generated from recurring partnerships.

Role Overview:

Join our multidisciplinary team to advance genetics-first drug discovery. You will plan and run targeted outreach, represent 5Prime at conferences and meetings, and prepare clear pre-meeting research and emails that enable high-yield introductions to clients. You’ll work with colleagues in genetics, bioinformatics, medicine, and software development to scope scientific projects, keep teams aligned, and ensure partners receive timely, accurate updates.

Success in this role requires a science-led, trust-first mindset, clear writing and speaking, strong organization, and the ability to move comfortably between science and business. By studying materials and working with the team, you’ll compile and present the value of our genetics-first approach to inform high-level partnership proposals.

Success will be measured by:

● Establishing high-yield business leads and introductions to potential clients.

● Attending and presenting at scientific conferences and meetings to establish business leads.

● Generate clear meeting summaries, with next steps, owners, and deadlines, and accurate updates.

● Establishing trust and scientific credibility with senior R&D stakeholders

Spécialiste sciences biologiques physiques sanitaires – Laboratoire de génétique médicale ( Glen )

Organization description

Le Centre universitaire de santé McGill (CUSM) est un centre hospitalier universitaire intégré, reconnu à l’échelle internationale pour l’excellence de ses programmes cliniques, de sa recherche et de son enseignement. Le CUSM a pour objectif d’assurer aux patients des soins fondés sur les connaissances les plus avancées dans le domaine de la santé et de contribuer au progrès des connaissances.

Website of the organization
cusm.ca

Equal Opportunity Employment Program

Le CUSM applique un programme d’accès à l’égalité en emploi et invite les femmes, les Autochtones, les minorités visibles, les minorités ethniques et les personnes handicapées à présenter leur candidature. Des mesures d’adaptation peuvent être offertes aux personnes handicapées qui en font la demande en fonction de leurs besoins.