Boris Steipe, PhD

Associate Professor, University of Toronto

Boris Steipe was born in Munich, Germany where he graduated from the medical school of the Ludwig-Maximilians University in 1985. He joined Andreas Plückthun’s lab at the Gene Center of the University for his PhD thesis on the recombinant expression and structure determination of an immunoglobulin fragment. Subsequently, his interests turned to protein engineering, and he joined Robert Huber’s Department at the Max-Planck Institute for Biochemistry in Martinsried, Germany in 1990. It was there that his “Canonical Sequence Approximation” – the hypothesis that sequence propensities can be used to predict stability changes in a very general way was first formulated.

Steipe was appointed Research Fellow at the Gene Center of the University, in 1990 and where his group worked on the rational stabilisation of immunoglobulin domains, on sequence determinants of protein folding and on the interplay of the protein matrix with the fluorophore in Green Fluorescent Protein; he was awarded his Habilitation in Biochemistry at the Faculty for Chemistry and Pharmacy of the University in 2000, when he was appointed as lecturer.

In 2001 Steipe moved to Toronto where he holds an appointment as associate professor in the Department for Biochemistry and the Department for Molecular Genetics, University of Toronto. His directed the University’s Specialist Program in Bioinformatics and Computational Biology from 2004 to 2019.