Broad Institute of MIT and Harvard, Imaging Platform
Cambridge
, Massachusetts
 United States
Postdoctoral
PhD
There are two projects:
– Rapidly identifying disease phenotypes from rare disease variants, and drugs to reverse their impact (as part of the NIH IGVF Consortium https://www.youtube.com/watch?
– Using Cell Painting, transcriptomics, and proteomics data to predict the toxicity of drugs and agrochemicals (as part of the OASIS Consortium https://oasisconsortium.org)Both projects will have copious data produced by this time next year!
Learn more here and apply: https://docs.google.com/
We seek a researcher to join our efforts to glean insights from large collections of images. There is much more information present in microscopy images than is commonly perceived by eye. We harvest this information, developing novel methods to characterize cellular populations at single-cell resolution. This work has the potential to transform how both the targets and therapies for disease are identified.
We aim to revolutionize the process of drug discovery in several projects, including:
- Identify the function of unknown genes and predict mutation impact, for personalized medicine
- Repurpose existing drugs to new diseases
- Identify new therapies for bipolar disorder and psychosis, based on cell morphology changes
- Predict how new chemical compounds act in cells
- Predict and classify toxicity of compounds destined for clinical trials or agrochemical use
Ph.D. required, in a quantitative discipline such as Computer Science, Bioinformatics, Computational Biology, Physics, or Math. Large-scale data analysis experience is required, as is enthusiasm for biology/biomedicine. Must demonstrate outstanding personal initiative, organizational ability, communication skills, and teamwork. In your cover letter, please describe your overall career interests, why this work would suit you, and what you would aim to learn. Please include specific examples of data analysis projects you have undertaken, including links to sample Python/R notebooks demonstrating your skills. Apply online at Broad Careers. Starting stipend is $70,000; more if you have experience post-PhD.
About us: Our lab’s mission is to uncover biological knowledge by developing advanced methods to quantify and mine the rich information in images. We love working as a team towards scientific goals: discovering the inner workings of biological systems and influencing patient treatment. We love making open-source software that impacts the world. We are conscientious and enjoy a professional, no-fuss environment, and are passionate about what we do while frowning on workaholism.
Postdoctoral position
Computational Biology
Broad Institute of Harvard and MIT
Carpenter-Singh laboratory
Biomedical research
Data Science
High-throughput imaging
CellProfiler software
Image analysis
Drug discovery
Cell Painting
Deep learning
Python/R notebooks
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