Clinical/Postdoctoral Fellow, PanCuRx

Ontario Institute for Cancer Research (OICR)
Toronto, ON
Job Description: 

Position: Clinical/Postdoctoral Fellow, PanCuRx
Site: MaRS Centre, Toronto
Department: PanCuRx, Translational Research Initiative
Reports To: Director, Pancreatic Cancer Translational Research Initiative
Salary: Commensurate with level of experience
Hours: 35 hours/week
Status: Full-time, Temporary (one to three years)

The Ontario Institute for Cancer Research (OICR) is seeking a motivated Clinical/Postdoctoral Fellow to drive analysis of genomic and transcriptomic data to support the PanCuRx Translational Research Initiative. We aim to significantly improve the lives of patients with pancreatic cancer by generating new knowledge about genetic and biologic subsets of disease, mechanisms of tumorigenesis, and unique treatment options. We are generating multiple independent genomic analyses including next-generation whole genome and whole transcriptome sequencing. Rich clinical annotation is also available for these samples, and analyses are performed on cutting-edge IT infrastructure including a multi-petabyte storage system and a >6,500-core compute cluster.

We are specifically looking for a unique candidate with clinical experience in the treatment of pancreatic cancer, and a track record in genomics and/or computational biology in the same field. The successful candidate will join a diverse team that includes bioinformaticians, statisticians, graduate students, postdoctoral fellows, surgeons, pathologists and medical oncologists.

• To identify actionable (druggable) aberrations and subtypes in genomes from pancreatic cancer tumours, and work with medical oncologists to propose individual treatment plans based on genomic profiles and pathway analysis (i.e. develop a personalized treatment approach for pancreatic cancer patients);
• To collaborate on the development of computational models for prediction of prognosis and treatment response;
• To identify predictive biomarkers based on data derived from preclinical models and patient samples;
• To develop hypotheses for functional validation and fundamental science relevant to pancreas cancer tumorigenesis.

• PhD in genomics, computational biology, or a related field and knowledge/experience in clinical treatment of pancreatic cancer; or MD with clinical expertise in treatment of pancreatic cancer and strong track-record in genomics and bioinformatics;
• Proven (peer-reviewed publication) experience with at least one of the following:
o Germline next-generation sequencing data analysis;
o Somatic next-generation sequencing data analysis;
o GWAS or genetic epidemiology;
o Proteomic data analysis;
o Bayesian statistical modeling;
o Survival analysis;
o Machine-learning;
o Systems biology; or
o Image-analysis (cellular or clinical imaging).

OICR is an innovative cancer research institute located in the MaRS Centre in the Discovery District in downtown Toronto. OICR is addressing significant challenges in cancer research with multi-disciplinary, multi-institutional teams. New discoveries to prevent, detect and treat cancer will be moved from the bench to practical applications in patients. The OICR team is growing quickly. We are innovative, dedicated professionals who bring expertise to each of our roles. We are looking for individuals interested in being part of a culture of excellence that will result in Ontario being recognized internationally as a leading jurisdiction for cancer research.

Launched in December 2005, OICR is an independent institute funded by the Government of Ontario through the Ministry of Research, Innovation and Science.

For more information about OICR, please visit the website at

POSTED DATE: August 2, 2017
CLOSING DATE: Until Filled

OICR is an inclusive employer dedicated to building a diverse workforce. We encourage applications from all qualified candidates and will accommodate applicants’ needs throughout all stages of the recruitment and selection process. Please advise the Recruiter to ensure your accessibility needs are accommodated throughout this process. Information received relating to accommodation will be addressed confidentially.

The Ontario Institute for Cancer Research thanks all applicants. However, only those under consideration will be contacted.

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