Postdoctoral Position in Evolutionary Genomics of Host-Pathogen Interactions

Institution/Company:
University Of Toronto
Location:
Toronto, ON, Canada
Job Type:
  • Postdoctoral
Degree Level Required:
PhD, Bachelor's
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Postdoctoral Position in Evolutionary Genomics of Host-Pathogen Interactions

A postdoctoral position for a computational biologist is available to study how bacterial pathogens evolve in the lungs of cystic fibrosis patients over the course of disease development and treatment. The project is in the laboratory of David S. Guttman in the Department of Cell & Systems Biology at the University of Toronto, Canada.. The specific project employs genomic data from >2000 longitudinal-collected strains of Pseudomonas aeruginosa to understand evolutionary dynamics, identify causative mutations, and predict antimicrobial susceptibility. The candidate will focus on computational analyses using evolutionary and comparative genomic, genome-wide association, and machine learning methods. There is also potential for metagenomic and microbiome investigation depending on the candidate’s interests. The position is part of a multi-institution Collaborative Health Research Project funded by the Canadian Institutes of Health Research and the Natural Sciences and Engineering Research Council of Canada.

The Guttman lab is a highly energetic and diverse group broadly focused on bacterial evolution in the context of host-microbe interactions. The lab aims to understand how bacterial pathogens adapt to changes in disease state or treatment over very short time scales in the CF lung; the evolution of host specificity and virulence and the emergence of new pathogens using the plant pathogen Pseudomonas syringae; and the role of microbial communities (microbiomes) in both human and plant health and disease. The Guttman lab is also closely associated with the Centre for the Analysis of Genome Evolution & Function (CAGEF), which is a genome centre with particular expertise in microbial and plant genomics and metagenomics. The genomic and bioinformatic resources afforded by CAGEF make the Guttman lab a particularly good place to work.

David S. Guttman Ph.D. Professor & Associate Chair for Research, Department of Cell & Systems Biology Director, Centre for the Analysis of Genome Evolution & Function University of Toronto Toronto, Ontario, Canada

Responsibilities:

Computational analyses using evolutionary and comparative genomic, genome-wide association, and machine learning methods. The individual will also be expected to be actively engaged with the rest of the lab and contribute to the research and training goals of the group.

Qualifications:

Interested applicants should have a Ph.D. (or be very close to completion) in population, evolutionary, or statistical genetics or genomics. A strong background is evolutionary biology, mathematics and / or statistics is preferred. Some computational experience is necessary. The positions is available for a minimum of two years, subject to annual review, and can be started immediately.

  • How to Apply

    To apply, please send: 1) a cover letter outlining your research interests, career goals, and previous experience; 2) a CV; and 3) contact information for three references to david.guttman@utoronto.ca

Additional Information

More information can be found at: Guttman lab:
https://guttman.csb.utoronto.ca/ https://scholar.google.ca/citations?user=SjuNdP0AAAAJ&hl=en The Centre for the Analysis of Genome Evolution & Function: http://www.cagef.utoronto.ca/ Department of Cell & Systems Biology: https://csb.utoronto.ca/

The University of Toronto is the top university in Canada and ranked within the top 20 world-wide. It provides an outstanding scientific environment with a highly interactive community of researchers. The Guttman lab and University of Toronto are strongly committed to diversity and especially welcomes applications from racialized persons, persons of color, women, Indigenous / Aboriginal People, persons with disabilities, LGBTQ persons, and others who may contribute to the further diversification of ideas. Toronto is a diverse, vibrant, and cosmopolitan city; one of the most desirable in the world in which to work and live.

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