Postdoctoral position to develop deep learning approaches in Computational Biology & Gene Regulation

Institution/Company:
Centre for Molecular Medicine Norway, University of Oslo
Location:
Oslo, Norway, Norway
Job Type:
  • Postdoctoral (24 months with possibility of extension)
Degree Level Required:
PhD
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Postdoctoral position to develop deep learning approaches in Computational Biology & Gene Regulation

A postdoctoral position is available in the Computational Biology & Gene Regulation group lead by Anthony Mathelier at the Centre for Molecular Medicine Norway (NCMM), University of Oslo, Nordic EMBL partner for Molecular Medicine (see http://mathelierlab.com for further information). The position is part of the recently funded project “Cis-regulatory signatures for improved identification and stratification of breast cancer subtypes” selected through the Rosa sløyfe 2020 – Personalized breast cancer treatment call by the Norwegian Cancer Society (Kreftforeningen). The position will start in the first half of 2021 and is offered for an initial two (2) years with possibility for extension.

We seek a highly motivated individual with a track-record of machine learning / deep learning models development ideally applied to high-throughput genomics data. We are looking for applicants excited about combining life sciences and computation to analyze gene expression regulation. The successful candidate will be collaborative, independent, with strong enthusiasm for research, and should have experience in programming (mainly Python, R, and bash) dedicated to the analysis of large-scale genomics data with a strong publication record. Being familiar with gene expression regulation in general, transcription factor binding, and the analysis of transcriptomics data (e.g. CAGE) analysis is an advantage. The position is open to applicants with a PhD in computational biology/bioinformatics, computer science, or related fields. We offer a stimulating environment with excellent working and social benefits.

Responsibilities:

The project aims at providing a map of active regulatory regions in breast cancer patients and developing machine-learning approaches to better stratify patients and identify breast cancer subtype cis-regulatory signatures. The selected candidate will specifically be involved in the implementation of a machine-learning approach to co-optimize the clusterization of patients and regulatory regions and will develop deep learning models to decipher the gene regulatory networks active in the identified cis-regulatory signatures. The developed methods will be applied to large experimental data sets publicly available as well as generated in house.

Qualifications:

  • PhD in computational biology, bioinformatics, biostatistics, or a related field
  • Strong publication records (including 1st authorship) with evidence for writing scientific manuscripts independently
  • Proficiency in programming (Python, R, bash)
  • Documented experience of machine learning / deep learning method development
  • Ability to collaborate with researchers from different fields and at different career stages
  • Willingness to be part of a team to share knowledge and skills
  • Documented ability to communicate science
  • Knowledge of eukaryotic gene expression regulation
  • Knowledge of molecular biology
  • Experience with analysis of genomics data sets
  • High drive for science and desire to become an independent researcher
  • Proficiency in English
  • Knowledge of CAGE (Cap Analysis of Gene Expression) data analysis is an advantage

Additional Information

We offer:

  • salary NOK 523 200 – 583 900 per annum depending on qualifications in position as Postdoctoral Research Fellow (position code 1352)
  • a professionally stimulating working environment
  • attractive welfare benefits and a generous pension agreement, in addition to Oslo’s family-friendly environment with its rich opportunities for culture and outdoor activities

The application must include:

  • a cover letter outlining motivations, career goals, past achievements, and research interests
  • a CV with list of publications
  • three referees (name, relation to candidate, e-mail and phone number)

These should be uploaded as a single PDF document.

The application with attachments must be delivered in our electronic recruiting system at https://www.jobbnorge.no/en/available-jobs/job/194647/postdoctoral-position-in-computational-biology-gene-regulation. Foreign applicants are advised to attach an explanation of their University’s grading system. Please note that all documents should be in English.

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