- Genome Sciences Centre
- Vancouver, BC, Canada
- Job Type:
- Degree Level Required:
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The cancer genomics projects will be to develop clinical assays for (1) Lymphoid cancers and (2) cancer monitoring and detection using blood samples (aka liquid biopsy). The successful applicant will work in a team to develop high-throughput, clinically accredited pipelines to aid in identifying pathogenic alterations in cancer. This project involves the development of new assays for cancer patients with the goal of individualized patient management.
Duties/Accountabilities: • Design, documentation, and analysis of experiments to test new assays and new methods • Summary and presentation of experimental findings to stakeholders • Modification and development of bioinformatic pipelines to analyze genomic data yielding clinical grade variant and expression data • Assist in choosing and modifying targets for assay development • Analysis of NGS data to investigate clonality, somatic hypermutation, microsattelite instability and intergenic translocations • Development and assessment of bioinformatic tools for RNA-Seq expression analysis and variant calling • Development and assessment of bioinformatic tools for determining the clinical significance of detected variants • Statistical analysis to determine analytical sensitivity and specificity of obtained results • Development of software pipelines for analyzing next-generation sequencing data • Support of research staff by providing analysis and software tools • Contributions to the writing of research publications
• Graduation from a recognized Bachelor of Science Program in Bioinformatics, Biological Sciences, Statistics, Engineering, or Computer Science. A Master’s or Doctoral degree in a relevant field would be a strong asset.
• Two (2) years of recent related experience or an equivalent combination of education, training and relevant experience.
Skills and Abilities: • Knowledge of RNA-Seq and other genomic data analysis, including expression analysis, structural variant detection, and variant-calling. • Experience working in a Unix environment, including experience with shell scripting and common command-line tools • Expertise in one or more scripting language(s) (e.g. Python) • Experience working with next-generation sequencing data and tools (i.e. tools for alignment and variant-calling) • Expertise in statistical analysis using modern computational tools. Experience with any relevant tools will be considered, but R and Python are preferred • Experience writing reports of results in accurate and concise language; expertise in scientific/technical writing is required • Experience with methods in high-dimensional data analysis for bioinformatics such as clustering, machine learning and data mining would be assets • Experience with software testing and cluster computing would be assets • Familiarity with cancer genetics would be an asset, as would a history of publications in relevant fields. The successful candidate will also have: • Excellent verbal and written communication skills • Demonstrated interpersonal skills including the ability to work effectively with others in a team environment. • Demonstrated ability to efficiently organize work assignments and establish priorities.
How to Apply
To apply for this position, please send your CV/resume with cover letter.