Bioinformatician

Institution/Company:
University of Calgary
Location:
Calgary, AB, Canada
Job Type:
  • Staff (1 year, with possibility to extend up to 5 years, apply by Aug 7, 2020)
Degree Level Required:
Masters, PhD
Apply Now

Bioinformatician

The University of Calgary’s Charbonneau Cancer Institute is participating in a multi-disciplinary translational research program called the Alberta Cellular Therapy and Immune ONcology (ACTION) initiative, which seeks to develop next-generation cellular immunotherapies and deliver them to cancer patients in Alberta and beyond. In bringing together basic, translational and clinical scientists and supporting them to achieve a shared mission, ACTION is establishing a unique ecosystem for translational research that will produce knowledge, inventions, collaborations, and commercial opportunities. We are looking for a bioinformatician to implement and develop workflows for multi-omic datasets generated through ACTION with the goal of identifying immunotherapy targets. There will be opportunities for additional collaborative projects, and teaching / training of junior personnel. The role is ideally suited for a self-driven individual with a strong analytic background and interested in working at the interface of genomics and translational medicine.

Responsibilities:

• Implement pipelines for analysis of bulk and single-cell RNAseq datasets

• Perform supervised and unsupervised analyses of expression differences at the gene, exon/isoform, and protein level using in-house and public datasets, using clustering and/or network approaches

• Implement pipelines to detect somatic alterations (including CNA/SVs, SNVs/indels), determine their clonality, and infer tumor phylogenies

• Predict the effect of coding mutations on protein structure and function, including HLA binding

• Integrate genomic, expression, and proteome datasets to identify candidates suitable for further development as cellular therapy targets

• Design and execute moderately complex in silico experiments with minimal supervision

• Maintain clear and accurate documentation

• Disseminate results through conference presentations and publications

• Establish and maintain effective and productive relationship with other members of Charbonneau and ACTION, and contribute to training of junior team members

• Provide accurate and timely milestone reports in accordance with project objectives and deliverables

Qualifications:

• Graduate degree in Bioinformatics, Computer Science, Molecular Biology, or related field

• Proficiency in at least one programming language (such as Python or R)

• Experience with Linux / Unix working environments

• Previous experience working on a high-performance computing cluster an asset

• Expertise with analysis and algorithm development on complex NGS datasets

• Excellent oral and written communication skills

Additional Information

About the University of Calgary

The University of Calgary is Canada’s leading next-generation university – a living, growing and youthful institution that embraces change and opportunity with a can-do attitude. Located in the nation’s most enterprising city, the university is making tremendous progress on its Eyes High journey to be recognized as one of Canada’s top five research universities, grounded in innovative learning and teaching and fully integrated with the community it both serves and leads. The University of Calgary inspires and supports discovery, creativity and innovation across all disciplines. For more information, visit ucalgary.ca. The University of Calgary recognizes that a diverse staff/faculty benefits and enriches the work, learning and research experiences of the entire campus and greater community. We are committed to removing barriers that have been historically encountered by some people in our society. We strive to recruit individuals who will further enhance our diversity and will support their professional success while they are here. We encourage all qualified applicants to apply, however preference will be given to Canadian citizens and permanent residents of Canada.

Keywords: