Research Fellow (Bioinformatician)

Institution/Company:
The Hospital for Sick Children
Location:
Toronto, ON, Canada
Job Type:
  • Programmer/Developer
Degree Level Required:
PhD, MD
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Research Fellow (Bioinformatician)

The Hospital for Sick Children, Toronto, Canada is one of the leading paediatric health care centres in the world, with an international reputation for excellence in health care, research, and teaching. Toronto is a large, safe, cosmopolitan city that offers the opportunity for a wonderful lifestyle combined with high-level academics. Our brain tumor research laboratory is currently seeking outstanding young scientists to join our group as Postdoctoral Research Fellows in computational cancer genomics. Successful candidates will be recent PhD graduates with high levels of energy and curiosity, and who are interested in making fundamental discoveries in understanding the molecular biology of brain tumours, and in pursuing eventual independent careers in academic research.

Research approaches in our group include genomics, cell biology, functional genomics, mouse modeling, developmental biology, stem cell biology, and translational ‘mouse-hospital’ approaches. Projects in the laboratory are all focused on malignancies of the central nervous system, and many have a direct connection to the clinic or to patient tumours. In particular, we are very interested in understanding recurrent and metastatic cancer, as this is the patient population in which most clinical trials are undertaken. Understanding the molecular basis of metastasis and recurrence after standard therapy could result in rapid clinical translation of novel therapies.

Employment Type: Research Fellow (Bioinformatician) Hours of Work: 35 hours per week; 2-year contract Department: Developmental & Stem Cell Biology Available Immediately Salary: Commensurate with experience Deadline: Until Filled

Responsibilities:

Job duties will include, but not be limited to:

• Quantifying and modeling tumour evolution and statistical modeling of outcome following treatment. • Develop new and innovative strategies for the analysis of cutting-edge single cell transcriptomic datasets to investigate gene function during normal mammalian brain development, and how abnormalities in normal brain development lead to the development of brain cancers. • Analysis and interpretation of data (whole-genome, whole-exome, ChIP-seq and RNAseq) in light of tumour evolution, with the aim of understanding the underlying dynamics of tumour growth, relapse, metastases and progression.

Qualifications:

Education: PhD or MD with previous training in bioinformatics, computer science, statistics or cell biology and possess exceptional computational skills. The most advanced Degree must have been conferred within the last 3 years.

Experience/Skills: • Experience with large-scale genomic data required. • Prior experience with brain development, and/or cancer cell biology would be an asset. • Prior first author publications are highly desirable. • Must be self-motivated, well-organized, highly independent, and willing to train new students. • Excellent communication, written and interpersonal skills are mandatory. • Candidates with external funding or scholarships to help support their salary will be highly recruited.

  • How to Apply

    Interested candidates should submit a detailed CV, research plan (one to two pages outlining your current research interests and/or research plans for the next 2 years), cover letter, and names and contact information for at least three references via e-mail.