Computational Biologist, Analysis

Canada's Michael Smith Genome Sciences Centre
Vancouver, BC, Canada
Job Type:
  • Programmer/Developer (Leave coverage - 2 years)
Degree Level Required:
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Computational Biologist, Analysis

The successful applicant will participate in the analysis of sequencing data by developing, refining and adapting bioinformatics tools for high-throughput processing pipelines. We seek candidates with strong coding experience in Python or other high-level object-oriented languages (e.g. C/C++, Java etc). Experience with statistical analysis and handling of biological data are also desirable. The role is ideally suited for a creative individual with a strong interest in software development and data analysis within an academic setting. Packaging and distribution of developed tools and analysis results to the scientific community and contribution to preparation of scientific publications are expected.


Duties/Accountabilities: • Develops and maintains core analysis pipelines at the GSC, such as: o Somatic and single sample variant calling on whole genomes, exomes and transcriptomes (eg SNVs, indels, CNVs, LOH) o De novo assembly of short read sequences and identification of putative structural variants. o Gene and transcript expression quantification and differential expression o Microbial classification and detection o New analyses pipelines as required • Performs statistical and population analysis of large cohorts of biological data. • Responds to analysis requests from the scientific community by running core pipelines, additional statistical analyses, suggesting analyses where appropriate, preparing presentations of results to collaborators and responding to collaborator questions on results. • Prepares data visualization for publication or oral presentations. • Presents results of analysis or software testing internally and externally • Performs literature searches, testing and validation of new data analysis software. • Performs other related duties as required.


Education, Training and Experience • Graduation from a recognized Bachelor of Science Program in Computer Science or equivalent with a significant genomics, statistical and computer science components. • Two years of recent related experience or an equivalent combination of education, training and experience acceptable to the GSC Group Leaders.

Skills and Abilities • Proven expertise with Python and or other similar high level languages • Demonstrated ability in R or other similar statistical programming languages and in statistical analysis • Ability to program and run analysis in a production environment • Functional knowledge of distributed version control systems, such as GIT • Excellent verbal and written communication skills. • Comfortable working in a Unix environment, including experience with shell scripting and common command-line tools • Demonstrated interpersonal skills including the ability to work effectively with others in a team environment. • Demonstrated ability to efficiently organize work assignments and establish priorities. • Previous experience in a bioinformatic setting, though not required, would be considered an asset

  • How to Apply

    To apply for this position, please email your CV and/or resume with cover letter