Postdoctoral Research Fellow

Institution/Company:
University of British Columbia
Location:
Vancouver, BC, Canada
Job Type:
  • Postdoctoral
Degree Level Required:
PhD
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Postdoctoral Research Fellow

Exciting postdoctoral training opportunity with the OVCARE Program at the University of British Columbia and the Department of Molecular Oncology at BC Cancer, studying the cellular origins of ovarian and other gynecological cancers through single cell sequencing technologies. The Department of Pathology at the University of British Columbia invites applications for a Postdoctoral Fellow. The successful applicant will work with Dr. Andrew Roth and Dr. David Huntsman as a part of the multidisciplinary OVCARE team (BC’s Gynecological Cancer Research Program, ovcare.ca) and bioinformatics team of the BC Cancer’s Department of Molecular Oncology (http://molonc.bccrc.ca).

We are studying the early events in ovarian cancer initiation by genetically manipulating organoids derived from normal tissues and transgenic mice. Our interest lies in dissecting the relative contributions of and interactions between cell of origin, mutation and microenvironment on the development of the common cancers of the uterus , ovary and fallopian tube.

Responsibilities:

For this particular project, ARID1A (a member of the SWI/SNF chromatin remodeling complex) is knocked out and mutant PIK3CA (a kinase involved in intracellular signaling) is introduced into the cells. Organoids are grown out from cells containing these genetic manipulations and single cell RNAseq, DNAseq and ATACseq will be performed. The successful candidate will integrate these datasets, as well as co-supervise students assigned to analyze other single cell sequencing datasets. We are looking for someone who has strong communication and leadership skills and who will work well in a group setting.

Qualifications:

  • PhD in Bioinformatics, Computer Science, Statistics or related fields.
  • Experience working with large genomic datasets.
  • Experience managing data from multiple sources and running bioinformatics pipelines.
  • Experience working with single cell RNA-Seq and/or single cell DNA-Seq.
  • Strong background in data science, machine learning preferred.
  • Programming skills in R and/or Python required.
  • How to Apply

    Email applications to Dr. Dawn Cochrane: dcochrane@bccrc.ca

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