Postdoctoral fellow in Regulatory Systems Genomics

Institution/Company:
McGill University
Location:
Montreal, QC, Canada
Job Type:
  • Postdoctoral
Degree Level Required:
PhD
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Postdoctoral fellow in Regulatory Systems Genomics

There are two openings for postdoctoral fellows (junior or senior) in the area of Computational Biology and Machine Learning in the COMBINE Lab. The projects are related to precision medicine and regulatory genomics in cancer and COVID-19, and involves collaborations with McGill Goodman Cancer Center, Mayo Clinic, Quebec COVID-19 biobank and Mila (Quebec AI Institute). This posting is related to developing probabilistic graphical models to identify regulatory mechanisms involved in drug resistance in cancer as well as disease severity in COVID19 using multi-omics data (RNA-seq, DNA-seq, ChIP-seq, ATAC-seq, etc.).

Responsibilities:

  • Develop and implement novel probabilistic graphical models for multi-omics analysis and reconstruction of transcriptional regulatory networks in cancer and COVID19
  • Analyze publicly available and in-house datasets containing DNA-seq, RNA-seq, ATAC-seq, ChIP-seq and clinical data
  • Collaborate with wet-lab researchers and machine learning experts on the project
  • Write scholarly articles and present the results of the project in scientific conferences

Qualifications:

1) A PhD degree in a related field (genetics, computational biology, computer science, machine learning, engineering, etc.) 2) Strong proven background (published work in peer-reviewed journals) in regulatory genomics 3) Proficiency in analyzing multi-omics data including (bulk and single cell) RNA-seq, ATAC-seq, ChIP-seq, DNA-seq, etc. 4) Proficiency in probabilistic graphical models (Bayesian networks, Markov random fields, variational inference, MCMC, etc.) 5) Strong programming skills (particularly in python) 6) At least two first-authored English papers (or three if co-first authors) with submitted, accepted or published status in peer-reviewed journals 7) Good spoken and written communication skills in English

  • How to Apply

    Interested applicants should submit 1) CV, 2) a letter of interest, 3) a research proposal and 4) a one-page summary of their most relevant publication, and 5) contact information for three references to Amin Emad (amin.emad@mcgill.ca). THe subject line of the email should read ‘‘Postdoctoral Application: Regulatory Systems Genomics’’. In the letter of interest, make sure to discuss how your background fits with the requirements of the position. The start date can be as early as Oct. 2020 and positions will remain open until filled. Please note that there is a separate postdoctoral opening in the area of Computational Biology and AI (see the other posting on this website).