Computational Biologist, Hirst Lab/Epigenomics Lab

University of British Columbia
Vancouver, BC, Canada
Job Type:
  • Programmer/Developer
Degree Level Required:
Bachelor's, PhD, Masters
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Computational Biologist, Hirst Lab/Epigenomics Lab

UBC Job Reference: JR6711

The main focus of the research in the Hirst lab is directed at understanding the role of epigenetics in cancer and investigating the therapeutic potential of interventions directed at epigenetic processes through a combination of innovative molecular biology and computational techniques. The lab is part of many national and international cancer research initiatives, including Marathon of Hope Cancer Centres Network and Canadian Epigenetics, Environment and Health Research Consortium.

The successful candidate will be embedded within a team of experimental and computational biologists and have access to a state-of-the-science epigenomic mapping pipeline and an extensive collection of reference epigenomic datasets from normal tissues, primary cancer tissues and cells and models.

This position is ideally suited to a creative individual with a strong interest in the operation and management of cutting-edge software for biological applications within an academic setting. The incumbent will be responsible for data management, conversion and analysis of next-generation sequence datasets using open source informatic tools.

For more detailed information about the research in the Dr. Hirst’s lab, please see To find out more about Dr. Hirst, including his position as Head of Epigenomics and Distinguished Scientist at Canada’s Michael Smith Genome Sciences Centre, please see


Duties and Responsibilities •Operating and improving a state of the art next generation sequencing data analysis pipeline. •Tracking and informatics management of large volumes of data with data footprints of up to 100Gb per experiment. •Performing sequence alignments, file merges and quality filtering using standardized tools. •Converting sequence alignments to normalized read densities and performing pairwise differential analysis. •Contributing to scientific grant proposals, presentations and publications.


Qualifications •Experience working in a Unix environment, including experience with shell scripting and common command-line tools. •Expertise in one or more scripting language(s) (e.g. Python, Perl, R, awk, C). •Familiarity with the development and maintenance of relational databases. •Experience working with next-generation sequencing data and tools would be an asset (i.e. tools for alignment and variant-calling). •Experience with statistical software, software testing, and cluster computing would also be assets.

Additional Information


Applicants should apply through this link (UBC Job opening ID: JR6711).

Posting End Date: April 8, 2022

PLEASE NOTE: The successful candidate will be a UBC employee working at Dr. Hirst’s lab on campus. UBC regulations regarding vaccine status and remote work will apply.

Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.

All qualified candidates are encouraged to apply; however, Canadians and permanent residents will be given priority.