- Ontario Institute for Cancer Research
- Toronto, Ontario, United States
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- Degree Level Required:
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Position: Bioinformatician II Site: MaRS Centre, Toronto Department: Genome Sequence Informatics Reports To: Manager, Genome Interpretation Salary: Commensurate with level of experience OICR Level: Level KN:05 Hours: 35 hours/week Status: Full-time Permanent The Ontario Institute for Cancer Research (OICR) is seeking a Bioinformatician II to join the Cancer Genome Interpretation group, part of Genome Sequence Informatics (GSI) and OICR-PM Joint Genomics Program (https://genomics.oicr.on.ca/).
Learn more about working at OICR here.
The Cancer Genome Interpretation (CGI) group is a team of bioinformaticians and genome interpreters developing analytic approaches for reporting clinical genomic data. The ideal candidate will have proven skills in both cancer genome biology and bioinformatic analysis. The Clinical Genome Analyst will collate sequencing results from clinical cases, identify and provide details on clinically actionable variation, and draft clinical reports for review by a board-certified Geneticist. In addition, the Analyst will develop and validate new cancer genome analysis approaches to incorporate into our suite of CAP- and IQMH- clinically accredited assays.
-Performing initial stage analysis on next-generation sequencing data transforming data from sequence to information meaningful for biologists; -Ensuring that data is managed efficiently, securely, and without loss or corruption through its lifecycle; -Providing bioinformatics support and training to end-users (research laboratory staff, remotely located collaborative users); -Responsibility for researching, planning, implementing, and testing bioinformatics software tools that meet the analysis needs for specific collaborative projects; -Development and support of protocols and workflows for standard analysis tasks; -Continuous interaction with the production development team to ensure that the NG sequencing software pipeline is consistently, reliably, efficiently and correctly processing data; -Interaction with collaborative research groups to explain next-generation sequencing capabilities and limitations, advise on experimental design, and present findings tools, techniques; -Work with 3rd party software vendors to characterize and resolve problems with production software systems; and -Responsibility for documenting and communicating pipeline processes and building the team knowledge base.
-Completion of a Master’s Degree or equivalent education or work experience; -Advanced skills in Linux shell programming environment; -Proficiency with some Linux based scripting language (Perl, Python etc.) required; -Competence with general purpose software development languages such as C, C++, Java preferred; -Experience with statistical and graphical software packages (R, Matlab) and associated bioinformatics libraries; -Must have excellent communications and interpersonal skills; -Willingness to be accessible and respond to production pipeline issues outside of normal working hours; Experience supporting a high availability production software environment; Experience providing end-user software support, diagnosing and resolving end-user issues; Experience working in a multidisciplinary team environment; and Experience working with data from the Illumina, Nanopore or other sequencing platforms is highly desirable.