Bioinformatician II

Ontario Institute for Cancer Research
Toronto, Ontario, United States
Job Type:
  • Staff
Degree Level Required:
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Bioinformatician II

Position: Bioinformatician II Site: MaRS Centre, Toronto Department: Genome Sequence Informatics Reports To: Manager, Genome Interpretation Salary: Commensurate with level of experience OICR Level: Level KN:05 Hours: 35 hours/week Status: Full-time Permanent The Ontario Institute for Cancer Research (OICR) is seeking a Bioinformatician II to join the Cancer Genome Interpretation group, part of Genome Sequence Informatics (GSI) and OICR-PM Joint Genomics Program (

Learn more about working at OICR here.

The Cancer Genome Interpretation (CGI) group is a team of bioinformaticians and genome interpreters developing analytic approaches for reporting clinical genomic data. The ideal candidate will have proven skills in both cancer genome biology and bioinformatic analysis. The Clinical Genome Analyst will collate sequencing results from clinical cases, identify and provide details on clinically actionable variation, and draft clinical reports for review by a board-certified Geneticist. In addition, the Analyst will develop and validate new cancer genome analysis approaches to incorporate into our suite of CAP- and IQMH- clinically accredited assays.


-Performing initial stage analysis on next-generation sequencing data transforming data from sequence to information meaningful for biologists; -Ensuring that data is managed efficiently, securely, and without loss or corruption through its lifecycle; -Providing bioinformatics support and training to end-users (research laboratory staff, remotely located collaborative users); -Responsibility for researching, planning, implementing, and testing bioinformatics software tools that meet the analysis needs for specific collaborative projects; -Development and support of protocols and workflows for standard analysis tasks; -Continuous interaction with the production development team to ensure that the NG sequencing software pipeline is consistently, reliably, efficiently and correctly processing data; -Interaction with collaborative research groups to explain next-generation sequencing capabilities and limitations, advise on experimental design, and present findings tools, techniques; -Work with 3rd party software vendors to characterize and resolve problems with production software systems; and -Responsibility for documenting and communicating pipeline processes and building the team knowledge base.


-Completion of a Master’s Degree or equivalent education or work experience; -Advanced skills in Linux shell programming environment; -Proficiency with some Linux based scripting language (Perl, Python etc.) required; -Competence with general purpose software development languages such as C, C++, Java preferred; -Experience with statistical and graphical software packages (R, Matlab) and associated bioinformatics libraries; -Must have excellent communications and interpersonal skills; -Willingness to be accessible and respond to production pipeline issues outside of normal working hours; Experience supporting a high availability production software environment; Experience providing end-user software support, diagnosing and resolving end-user issues; Experience working in a multidisciplinary team environment; and Experience working with data from the Illumina, Nanopore or other sequencing platforms is highly desirable.

Additional Information

OICR is a collaborative, not-for-profit research institute accelerating the development of new cancer research discoveries for patients around the world while maximizing the economic benefit of this research for the people of Ontario. We are dedicated professionals who bring expertise to each of our roles. We are looking for individuals who share our values of excellence, innovation, collaboration, impact, responsibility and community.

Launched in December 2005, OICR is an independent institute funded by the Government of Ontario through the Ministry of Colleges and Universities.

For more information about OICR, please visit the website at

CLOSING DATE: Until Filled

OICR is an inclusive employer dedicated to building a diverse workforce. We encourage applications from all qualified candidates and will accommodate applicants’ needs throughout all stages of the recruitment and selection process. Please advise the Recruiter to ensure your accessibility needs are accommodated throughout this process. Information received relating to accommodation will be addressed confidentially.

The Ontario Institute for Cancer Research thanks all applicants. However, only those under consideration will be contacted.

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