Postdoctoral Fellow (Computational Biology – Synthetic Lethality in Cancer)

Institution/Company:
University College Dublin
Location:
Dublin, Dublin, Ireland {Republic}
Job Type:
  • Postdoctoral (3 Years)
Degree Level Required:
PhD
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Postdoctoral Fellow (Computational Biology – Synthetic Lethality in Cancer)

The Ryan group at Systems Biology Ireland and the UCD School of Computer Science are recruiting postdoctoral fellows to work on computational approaches to understand and predict synthetic lethal interactions in cancer.

Project Description: Synthetic lethality, where one gene becomes essential in the presence of a mutation in another, has emerged as a promising approach by which we might identify new therapeutic targets for a variety of cancer associated mutations. Advances in genetic screening technologies, most notably CRISPR gene-editing, have enabled large- scale efforts to identify new synthetic lethal targets in cancer. However, testing all human gene pairs for synthetic lethality in even a single cell line is well beyond the field’s current capacity. Furthermore, it has become clear that synthetic lethal interactions are highly context-specific: a combination of genetic perturbations that is lethal in one cell type or genetic background may be well tolerated in another. The nature of this context-specificity and the factors that influence it are almost entirely unknown. However, such knowledge is critical both for identifying new synthetic lethal therapies and for anticipating resistance to such therapies. The overall goal of this project is to understand what factors contribute to the context-specificity of synthetic lethality in cancer and to develop machine learning models capable of predicting context-specific synthetic lethality. Relevant recent papers from our lab include Lord et al, eLife (2020) and De Kegel et al, Cell Systems (2021).

This is a research focused role, where you will conduct a specified programme of research supported by research training and development under the supervision and direction of a Principal Investigator.

The primary purpose of the role is to further develop your research skills and competences, including the processes of publication in peer-reviewed academic publications, the development of funding proposals, the mentorship of graduate students along with the opportunity to develop your skills in research led teaching.

Responsibilities:

• Conduct a specified programme of research and scholarship under the supervision and direction of your Principal Investigator. • Engage in appropriate training and professional development opportunities as required by your Principal Investigator, your School or Institute, or the University. • Engage in the dissemination of the results of the research in which you are engaged as directed by and with the support of and under the supervision of your Principal Investigator. • Engage in the wider research and scholarly activities of your research group, School and Institute. • Mentor and assist, as appropriate and as directed, the research graduate students in your group, School and Institute. • Carry out administrative work associated with your programme of research.

Qualifications:

PhD in Computational Biology / Bioinformatics / Genomics / Systems Biology Experience in programming and computational data analysis A demonstrated commitment to research and publications An understanding of the operational requirements for a successful research project Evidence of research activity (publications, conference presentations, awards) and future scholarly output (working papers, research proposals, and ability to outline a research project. Excellent Communication Skills (Oral, Written , Presentation etc). Excellent Organisational and Administrative skills including a proven ability to work to deadlines. Candidates must demonstrate an awareness of equality, diversity and inclusion agenda.

Additional Information

For informal queries please contact Colm Ryan by email

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