Post-doctoral Fellow in Computational Protein Structural Biology

Institution/Company:
The Hospital for Sick Children Research Institute
Location:
Toronto, ON, Canada
Job Type:
  • Postdoctoral
Degree Level Required:
PhD
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Post-doctoral Fellow in Computational Protein Structural Biology

The Forman-Kay lab is seeking a talented post-doctoral fellow able to fulfill the responsibilities and requirements below. The successful applicant will be part of a collaborative team including Teresa Head-Gordon at UC Berkeley and Claudiu Gradinaru at the University of Toronto that aims to develop computational methodology building on our previous work (ENSEMBLE, X-EISD) for describing ensembles of intrinsically disordered protein (IDP) conformations consistent with experimental NMR, SAXS and single molecule fluorescence data. These ensembles will include isolated IDPs as well as dynamic complexes of IDPs with folded proteins and large-scale associated complexes representing condensed protein states following phase separation. There will be rich opportunities to participate in academic activities within the Research Institute at the Hospital for Sick Children as well as with the affiliated University of Toronto, including very strong and collaborative scientific communities interested in protein structural biology, IDP biophysics and biomolecular phase separation.

The Forman-Kay lab is located in The Hospital for Sick Children (SickKids), Canada’s most research-intensive hospital, in downtown Toronto. The SickKids Research Institute housed in the Peter Gilgan Centre for Research and Learning (PGCRL) building includes over 2,000 researchers, trainees, and staff working together on the toughest challenges in biomedical science, with a focus on children’s health. Innovation and collaboration across our seven distinct research programs have led to numerous discoveries at SickKids, from fundamental biology to uncovering the mechanisms and outcomes of disease. The Forman-Kay lab is within the Molecular Medicine Program, focused on developing molecular approaches for the prevention, diagnosis, and treatment of human diseases by understanding and identifying molecular structures and mechanisms. Molecular Medicine is internationally recognized as one of the leading centres for structural biology worldwide, combining biophysical, computational, chemical, biochemical, microbiological, and cell biological tools to study the molecular foundations of normal and pathological processes.

Responsibilities:

  • Develop computational approaches for describing intrinsically disordered protein structural ensembles consistent with experimental NMR, SAXS and single molecule fluorescence data, including dynamic complexes with folded proteins and condensed phases
  • Apply these approaches to key protein systems and analyze the results with respect to experimental data and biological function
  • Create and maintain computational resources to facilitate use of these computational tools by the intrinsically disordered protein community
  • Communicate progress regularly with collaborative team and contribute to the success of the project, including by maintaining productive collaboration
  • Publish and present novel research findings in academic journals and conferences
  • Occasionally supervise trainees and technical staff

Qualifications:

  • PhD degree in protein structural biology, bioinformatics, computer science, computational biology, or a related field
  • Outstanding programming skills in Python and Unix shell scripting
  • Track record of developing computational tools and analysis of protein structural data
  • Strong attention to detail and solid analytical skills
  • Ability to work hard and independently while contributing to the team effort
  • Excellent oral and written communication skills with track record of productive collaborations leading to publications
  • How to Apply

    Interested and qualified candidates should submit a CV and detailed letter of interest to Julie Forman-Kay (forman at sickkids.ca).