Scientific Associate II, Computational Biology

Ontario Institute for Cancer Research
Toronto, ON, Canada
Job Type:
  • PhD
Degree Level Required:
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Scientific Associate II, Computational Biology

Position: Scientific Associate II, Computational Biology Site: MaRS Centre, Toronto Address: 661 University Avenue, suite 510 Toronto, Ontario. M5G 0A3 Department: Computational Biology Reports To: Lincoln Stein Salary: $87,667 - $103,138 per annum Hours: 35 hours/week Status: Full-time, Permanent

The Ontario Institute for Cancer Research (OICR) is seeking a permanent, full-time Scientific Associate to join the Computational Biology team.

Learn more about working at OICR here.

The Scientific Associate will participate in projects relating to the development of cancer therapeutics and companion biomarkers. The candidate must have a PhD in Biological Sciences, research experience in the areas of cancer and cancer therapeutics, and a strong combination of wet laboratory and data analytic skills. The Scientific Associate will work under the supervision of Dr. Lincoln Stein on projects relating to the U1 spliceosome mutation in CLL and other cancers and will participate in other cancer biology projects involving the creation of multi-modal prognostic biomarkers.

To find out more about what’s happening in Computational Biology, visit OICR news.


-Wet laboratory work relating to characterizing patient samples carrying U1 gene mutations: -PCR screening of CLL and HCC tissue samples to identify those carrying U1 gene mutations. -Phenotypic characterization of cell lines carrying U1 gene mutations after treatment with splice modulator compounds, including cell growth and motility assays. -Preparation of U1 mutant tissue sample for long-read sequencing. -Perform analysis of long-read data from U1 mutant tissue samples to identify neoantigens and to discover motifs predictive of alternative splicing in U1 mutant background. -Database searches for cell line models and banked tissues carrying mutations in U1 and other spliceosome RNAs. -Curation and validation of published genomic theranostic biomarkers for breast cancer. -Development of algorithms for combining breast cancer biomarkers with imaging biomarkers to increase accuracy. -Preparation and analysis of Feulgen-stained cancer tissues for spatial ploidy determination. -Relation of spatial ploidy to clinical outcome in breast, pancreatic and other cancers. -Computational analysis relating to U1 gene mutation: -Responsibilities relating to other projects: -Preparation of publications and grant proposals in partnership with Dr. Stein.


-A PhD in biological sciences; -Minimum six (6) years of relevant academic or professional experience; -Competence in the following bench techniques: nucleic acid extraction, cell culture, immunofluoresence, cell growth and motility assays, PCR, 5’RACE, vector construction, and dosage-response assays; -Experience in the following data analysis areas: Oxford Nanopore long-read sequence analysis for isoform quantification, prediction of immunogenic peptides, sequence database search, dose-response curve generation, normalization and quantification of gene expression using microarray and/or RNA-seq; -Competence with the following software tools: a high level scripting language such as Python or Perl, data analysis with R, source-code control with GitHub; -Experience in the preparation of grants, publications and presentations; -Excellent communication skills; and -All candidates must be able to function proficiently in English.

Additional Information

OICR is a collaborative, not-for-profit research institute accelerating the development of new cancer research discoveries for patients around the world while maximizing the economic benefit of this research for the people of Ontario. We are dedicated professionals who bring expertise to each of our roles. We are looking for individuals who share our values of excellence, innovation, collaboration, impact, responsibility and community.

Launched in December 2005, OICR is an independent institute funded by the Government of Ontario through the Ministry of Colleges and Universities.

For more information about OICR, please visit the website at

Salary: $87,667 - $103,138 per annum

Benefits: Group Benefits, Ten Sick Days per year, Long Term Disability, SunLife Group Benefits, Life Coverage, Vision care, Accidental Death & Disbursements, Extended Health Care, Dental Care, Pension Plan and 20 days paid vacation per year.

CLOSING DATE: July 30, 2021


All interested candidates are asked to please submit their Cover Letter & Resume online at

OICR is an inclusive employer dedicated to building a diverse workforce. We encourage applications from all qualified candidates and will accommodate applicants’ needs throughout all stages of the recruitment and selection process. Please advise the Recruiter to ensure your accessibility needs are accommodated throughout this process. Information received relating to accommodation will be addressed confidentially.

The Ontario Institute for Cancer Research thanks all applicants. However, only those under consideration will be contacted.

Resume Format: If you elect to apply, you will need a text or HTML version of your resume so that you can cut and paste it into the application box provided. Before you submit the completed application, you will be asked to attach one or two files to your application. Please attach your resume as a .pdf or .doc file.