Manager of Bioinformatic Analysis Platform in Single-Cell Sequencing

Institution/Company:
Centre de recherche du CHU Sainte-Justine
Location:
Montréal, QC, Canada
Job Type:
  • Staff
Degree Level Required:
PhD
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Manager of Bioinformatic Analysis Platform in Single-Cell Sequencing

The Single-cell Sequencing Bioinformatics Platform is a new scientific research platform from the Research Department of CHUSJ, an initiative dedicated to pediatric hemato-oncology, which will meet the needs of researchers in terms of innovative technology in order to develop strong local expertise in this rapidly expanding sector, by setting up an analysis platform. This platform is looking for a computational biologist highly qualified in bioinformatics and cancer biology, whose main mandate will be to support the researchers of the Research Center in their analyzes. The candidate must be able to carry out different types of analyzes related to the most common approaches in single cell genomics (expression, ATAC, V(D)J, CITE-seq, mutations, etc.) and in “bulk” approaches including but not limited to the exome, the transcriptome and the whole genome. The recruited candidate should be able to adapt quickly to new technologies introduced by research teams and be able to analyze pilot experiences from emerging technologies. He must also have excellent communication skills, help democratize the analyzes carried out, train team members and participate in the scientific life of the Research Center.

The incumbent will be primarily responsible for providing the necessary support to researchers and research teams with regard to the development and execution of the analyzes offered by the platform. More specifically, the incumbent will be responsible for the development of the platform’s infrastructure and service offer at the Research Center, considering that this infrastructure aims to support the performance of bioinformatics analyzes in cancer biology. You will act as a resource person for any question related to your various functions and responsibilities with researchers and research staff, depending on the type of file to be processed.

Responsibilities:

Under the direct supervision of the Manager of the common scientific platforms of the Research Directorship and in close collaboration with its scientific director Dr Vincent-Philippe Lavallée, the candidate will have, gradually and according to the priority projects, various responsibilities:

• Complete mature analyzes from raw single cell sequencing data, including documenting and communicating the analysis process, results, tools and techniques used; • Advise research teams seeking to generate single cell-type data on the experimental design; • Interact fluently with members of different research teams in order to develop appropriate analysis strategies; • Manage and coordinate the bioinformatics work carried out in the platform; • Develop and write procedures for processing data on the platform; • Organize and prioritize data on Compute Canada’s servers; • Work on the plan for infrastructure related to bioinformatics and data storage; • Coordinate technical and scientific communications with collaborators at the research center; • Coordinate and plan the monthly invoicing of the services offered on the platform, while respecting the fee schedule in effect. Participate when relevant, in establishing competitive prices based on benchmarking analyzes in the healthcare network; • Communicate to the client in an efficient and effective manner; • Provide training and orientation for new employees.

Qualifications:

Requirements: • Ph.D. in bioinformatics, computer science or equivalent. Work experience in the field or a related post-doctoral internship will be considered an advantage; • Demonstrated experience in conventional genomics and single cells; • Strong understanding of cancer biology and molecular biology; • Contribution to scientific publications in genomics; • Code experience in more than one of the following languages: python, R, C ++, Matlab, etc. • Experience with relational databases (eg MySQL); • Good competence in “Data management”; • Proactive and able to work independently; • Excellent speed of execution, sense of organization and time management; • Strong interpersonal skills and team spirit; • Great adaptability and ease in implementing or using new algorithms; • Ability to work effectively, strong skills in stress management; • Fluency in French and English in the workplace;

Competence profile: • Be an excellent team leader to serve the needs of the community; • Demonstrate initiative, resourcefulness and autonomy; • Good interpersonal skills and excellent customer service; • Ability to work under pressure and manage priorities effectively; • Use good judgment and good judgment.

Additional Information

Conditions of employment:

This is a full-time (35 hrs/wk), non-unionized position (one year probation period). Compensation according to the current salary scale at CHU Sainte-Justine and based on years of relevant recognized experience.

Expected start date: Immediately

IMPORTANT NOTICE We would like to point out that foreign applicants must have a valid work permit for the CHU Sainte-Justine. Any work permit with the following condition will not be eligible: “Not authorized to work in childcare, primary/secondary school teaching, health service field occupations”

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