Postdoc position in computational population genetics

Institution/Company:
Technical University of Denmark (DTU)
Location:
Copenhagen, Hovedstaden, Denmark
Job Type:
  • Postdoctoral
Degree Level Required:
Bachelor's, PhD, Masters
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Postdoc position in computational population genetics

In this position you will develop algorithms and computational methods to deal with the analysis of large datasets from modern and ancient sources. More specifically, these algorithms will be aimed at analyzing a large number of ancient genomes using population genetics methods. The bioinformatics section of DTU Health Tech performs research in the areas of different metagenomics, machine learning, cancer genomics and population genomics. Additional information should be obtained by contacting the potential main supervisor directly. The university is located in the greater Copenhagen area, which is acknowledged for its excellent standards of living, childcare and welfare system.

Current bioinformatics algorithms and software are often ill-equipped to deal with DNA extracted from ancient populations. This ancient DNA shows high levels of fragmentation and accumulated chemical damage. Furthermore, the number of individuals that can be sequences is often limited. Fortunately, several problems pertaining to ancient DNA and ancient paleogenetics can be described in a maximum-likelihood framework and computer science techniques can help us to solve such numerical problems efficiently via machine learning, numerical algorithms and data structures. You will work in collaboration with other partners including the University of Copenhagen in order to develop the next generation of algorithms and software applied to DNA from fossils which can then be used to reconstruct population history and infer selection.

Given the COVID19 pandemic, we will happily accommodate requests for remote work until in-person work is deemed safe.

Responsibilities:

To develop algorithms and computational methods to deal with the analysis of large datasets from modern and ancient sources.

Qualifications:

Qualifications You must hold a PhD degree (or equivalent) ideally in biological science with a focus on quantitative and mathematical aspects, or in computer science or mathematics.

The candidate we are looking for should ideally have the following qualifications:

  • Knowledge of a programming language like Python, Perl, C++ and/or Java
  • Ability to work in a UNIX environment, ideally in a high-performance computing environment
  • Ideally, proficiency in C/C++ or Java or similar is a plus (not required)
  • Thorough understanding of basic principles of population genetics
  • Knowledge of probabilities and statistics
  • Firm grasp of first-year university mathematics (differential calculus/linear algebra)
  • Knowledge of coalescence theory or diffusion theory is an advantage
  • Expertise in next-generation sequencing data generation and processing are also a plus

The language of communication at DTU is English