Research Associate

Institution/Company:
The Hospital for Sick Children
Location:
Toronto, ON, Canada
Job Type:
  • Staff
Degree Level Required:
PhD
Apply Now

Research Associate

The Research Associate (Genomicist, Genome analyst, Research Genetic counsellor) will play a key role in the design, planning, and implementation of the Ted Rogers Cardiac Genome Research Clinic (a unique collaboration with SickKids, University Health Network, and the University of Toronto). The Research Associate will liaise with The Centre for Applied Genomics (TCAG) and internal and external project stakeholders to ensure the project aligns to achieve the targeted outcomes.

The primary responsibility for this role will be to support the development, implementation and maintenance of the analysis pipeline of the cardiac genomic sequencing data. This involves working closely with a team of research genome scientists from TCAG, the Labatt Family Heart Centre, the Centre for Genetic Medicine, bioinformaticians and clinicians to analyze and interpret genetic and phenotype data from a diverse population with cardiac disease.    

As this area of cardiac genetic analysis is rapidly developing, the Research Associate will be responsible for keeping abreast of new developments in genomic analysis as it applies to cardiology and incorporating advances in the field into clinical service.

Responsibilities:

  • To work with ongoing collaborations with clinicians, research scientists and bioinformaticians to identify new genomic analytic methodology.

  • To coordinate the in-depth analysis of samples with team members conducting and interpreting genomic analysis and variant interpretation.

  • To conduct the development, validation and implementation of new genomic analytic tools and technologies for use in the laboratory and ensure that they meet the needs of the clinical programs of the Hospital.

  • To participate in strategic planning, implementation and ongoing development of the Cardiac Genome Clinic, particularly as it relates to implementation of latest sequencing technologies into clinical diagnostics to directly benefit Canadian and international health care.

  • To work within the framework of the Ted Rogers Centre for Heart Research and TCAG, and with stakeholders from the Division of Clinical and Metabolic Genetics, the Centre for Computational Medicine (CCM), and the Labatt Family Heart Centre to introduce and support clinical whole genome sequencing into its molecular diagnostics laboratory to serve the Cardiac Genome Clinic and SickKids/UHN in general.

  • To ensure that written procedures/protocols are developed and approved for each methodology implemented and the ongoing review and approval of all changes at an established frequency to ensure protocols remain current with advances in technology and laboratory practice.

  • To liaise with the Genome Diagnostics/TCAG to establish appropriate procedures for recording and reporting of genomic test results within defined time expectations (TATs).

  • To work with the clinical investigators/collaborators on translational research initiatives, including the follow-up of new genomic testing and reporting and in the development of new knowledge to extend the utility of cardiac genomic testing.

  • To establish resources (patient and control cohort collections, data sets, and infrastructure) available for broad use in the long term by the Canadian and international scientific and clinical communities

  • To continually update professional knowledge and skills through reading scientific literature and attending national and international conferences.

  • To augment the stature of the hospital through excellence in genomic research, teaching and/or participation in national and international genetic organizations.

Qualifications:

  • PhD and post-doctoral training in human molecular genetics, population genetics, cardiac genomics or related field.

  • Certification by the CCMG or ACMG in molecular genetics (preferred).

  • OR Master’s in Genetic Counselling (ABGC, CAGC) with experience in variant interpretation

  • Previous training or experience in human genomic analysis (experience with cardiac disease an asset).

  • Demonstrated ability to conduct independent research and experience in the development of research manuscripts.

  • Broad understanding of the latest research tools and techniques and developments in genomic technology bioinformatics and variant interpretation as it pertains to genetic cardiac diagnostics.

  • Strong problem solving skills and the ability to analyze complex problems.

  • Excellent communication skills and the ability to work in a team environment.