- The Hospital for Sick Children (SickKids)
- Toronto, ON, Canada
- Job Type:
- Degree Level Required:
- Apply Now
The Hospital for Sick Children is looking for talented and motivated Bioinformatician to work in the field of clinical molecular diagnostics. The successful candidate will join a multidisciplinary team employing modern sequence-based techniques including genome wide sequencing to better diagnose and treat genetic disease. The group is situated in the Division of Genome Diagnostics and works closely and collaboratively with The Centre for Applied Genomics. This is a unique opportunity to use your informatics skills to impact patient care.
Genome Diagnostics is the largest CLIA certified laboratory in Canada and is working on a number of projects, whose aims include:
- Translation of new sequencing technologies and methods into routine clinical practice.
- Developing and implementing exome and genome sequencing as diagnostic tests.
- Building databases and data sharing capacity to better interpret genomic variation for clinical use.
Here’s What You’ll Get To Do
- Develop and maintain custom software as well as utilize commercial and open source software to help understand clinical genomic data and to support ongoing translational research activities.
- Keep abreast of new and emerging technologies, and suggest new ways of analyzing and integrating very large data sets to better understand the causes of rare disease.
- Work with genome scientists and genetic counsellors to ensure bioinformatic tools are incorporated into the clinical workflow to meet the need for efficient and correct interpretation of genomic data in the diagnostic process.
- Build, test, and maintain analysis pipelines and manage instances using both onsite computing clusters and cloud based solutions.
- Develop standard operating procedures, documentation, and validation documents that conform to CAP/CLIA requirements.
Here’s What You’ll Need
- Minimum of a Masters Degree, or equivalent experience, in a relevant field such as bioinformatics, mathematics or computer science.
- Advanced understanding of computer science and bioinformatics including a basic understanding of human genetics.
- Experience with next-generation sequencing analysis and genome-wide sequencing strategies such as exome and genome sequencing.
- Demonstrated programming abilities (Python, Perl etc.) and familiarity with Unix, and high-performance computing.
- Familiarity with statistical genomics and/or experience with developing, testing and maintenance of databases (MySQL/MongoDB) is an asset.
- Excellent verbal and written communication skills.
- Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.