Bioinformatics post-doc, similar to single cell analysis

Institution/Company:
McGill University
Location:
Montreal, QC, Canada
Job Type:
  • Postdoctoral (Funding guaranteed)
Degree Level Required:
PhD
Apply Now

Bioinformatics post-doc, similar to single cell analysis

Exosomes are stable nanometer‐sized vesicles that are secreted by human cells into the blood stream. Exosomes carry unique molecular compositions representative of the parent cell, and in this sense an exosome “fingerprint” can be used to identify a parent cell, be it a cancer cell or a healthy cell. The information content carried by exosomes has recently emerged as a key biological signal for cancer diagnosis and progression. However, although exosomes can be obtained from blood in clinical settings, current exosome analysis tools only measure the average signal of bulk exosome mixtures, losing the precious cell- specific information encoded at the single exosome level that reflects the heterogeneous diversity of the parent cancer cells.

Job Duties
This project will focus on the preprocessing and analysis of a newly developed technology for single-exosome profiling. As such, the candidate post-doc is expected to apply and modify current technologies for profiling single-cell data to exosome profiling. Example technologies include tSNE, Phenograph to quantify single exosome heterogeneity and to identify subpopulations of exosomes (EX). Trajectory based approaches, for example Wishbone and Monocle, will also be useful to identify gradual changes in EX profile.

Responsibilities:

Development of new algorithms
Documentation and unit tests
Other duties as assigned

Qualifications:

PhD in computational biology, bioinformatics, computer science or related field.
Experience in dealing with single-cell analysis such as single-cell RNA-seq (scRNAseq), cytometry (CyToff) or similar genome-wide single-cell data such as methylation.
Programming skills sufficient to creating, modifying and debugging relevant algorithms.
Ability to work independently and a self-motivated person.
Basic understanding of biology
Bonus - Matlab programming skills.
Bonus - Basic understanding of cancer biology.

  • How to Apply

    Email CV, Cover letter

Additional Information

Starting date: ASAP
Competitive funding guaranteed for 2 years.

McGill is one of the world’s top universities, ranking 1st in Canada among medical-doctoral universities (Maclean’s) and 32nd in the world (QS World University Rankings). In 2018, the University ranked among Montreal’s Top Employers. McGill is located in Montreal, the most populous municipality in the Canadian province of Quebec and the second-most populous municipality in Canada. As such, Montreal is a vibrant city, famous for its Jazz festival and culture.

Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit or Indigenous person. All qualified candidates are encouraged to apply.

Keywords: