Research Programmer - Clinical Genomics

Genome Sciences Centre
Vancouver, BC, Canada
Job Type:
  • Programmer/Developer
Degree Level Required:
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Research Programmer - Clinical Genomics

The successful applicant will work closely with the Clinical Genomics group which is responsible for developing high-throughput, clinically accredited pipelines to aid in identifying pathogenic alterations in cancer. This role involves designing assays using circulating cell-free DNA which is extracted from a patient’s blood and is then sequenced creating a bioinformatic dataset of the targeted DNA. This role involves assessment of third-party bioinformatic tools to design a pipeline to detect genetic variants and determine their clinical significance.


• Independently researching genes and mutations involved in cancer or disease of interest. • Design bioinformatic pipelines by identifying candidate software to consider, comparing software candidates to aid in selection, and determining optimal parameters for the chosen software. • Performs bioinformatics analyses to answer questions from the Medical Director and/or research team. • Presents implementation plans, analysis results, and validation results internally and externally, in oral presentations and written documentation. • Statistical analysis to determine analytical sensitivity and specificity of obtained results. • Development of software pipelines for analyzing next-generation sequencing data. • Support of research staff by providing analysis and software tool evaluations. • Contributions to the writing of research publications.

Skills and Abilities: • Demonstrated ability in R or other similar statistical programming languages. • Ability to build analysis workflows and perform reproducible analyses in a research environment. • Comfortable working in a Unix environment, including experience with shell scripting and common command-line tools. • Functional knowledge of distributed version control systems, such as Git. • Familiarity with next-generation sequencing, cancer genetics, principles of clinical testing, experimental design, statistical hypothesis testing, and/or machine learning would be considered an asset. Publications in relevant field(s) would be a strong asset. • Previous experience in a bioinformatic setting would be considered an asset. • Familiarity with workflow languages (such as CWL) would be considered an asset. • Demonstrated skill with Python or other similar high level languages would be considered an asset. • Ability to use related equipment. The successful candidate will also have: • Excellent verbal and written communication skills • Demonstrated interpersonal skills including the ability to work effectively with others in a team environment. • Demonstrated ability to efficiently organize work assignments and establish priorities.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.


• Graduation from a recognized Bachelor of Applied Science or Bachelor of Science Program in either Biological Sciences or Computer Science. An MSc or PhD would be an asset. • Two (2) years of recent related experience or an equivalent combination of education, training and experience acceptable to the GSC Group Leaders.

  • How to Apply

    To apply for this position, please send your resume with cover letter.

Additional Information

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.