Architect I - Senior Software Developer

University Health Network - Princess Margaret Cancer Center
Toronto, ON, Canada
Job Type:
  • Programmer/Developer
Degree Level Required:
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Architect I - Senior Software Developer

The laboratory of Dr. Trevor Pugh, PhD, FACMG is looking for a cloud-focused, senior software developer to help lead a team charged with continuing development and interconnection of scientific software, including cBioPortal and the CanceR Single Cell Expression Toolkit (CReSCENT), a cancer single cell expression portal and distributed database to aggregate and store single-cell genomics. This will include deployed on institutional and commercial cloud platforms including HPC4Health ( and Microsoft Azure. All of our work is open source (, and we collaborate widely with researchers across Canada and the US (e.g.,, and Our group brings together experts from a variety of disciplines including medicine, genomics, immunology, high performance computing, machine learning, and pathology. We are an active part of the Princess Margaret Cancer Genomics and Tumour Immunotherapy programs ( and In this role, we are developing a range of web applications that support clinicians and researchers across the Princess Margaret Cancer Centre, enabling them to share and transform data for clinical and research use. We also work closely with the OICR Genomics program ( to support data sharing across numerous precision medicine projects. This is an exceptional opportunity to have broad impact across the spectrum of cancer research projects.


• Lead the development team and ensure timely delivery of work • Mentor junior team members • Extend or implement web solutions for analyzing and virtualizing next generation sequencing and other genomic data. • Maintain and document current code base and exiting web services • Develop robust pipelines for standardized of single-cell genomics data • Design architecture to efficiently handle high dimensional and complex datasets • Experience working with open-source software


• University Degree in Computer Science, Computer Engineering, Bioinformatics, or a similar discipline. • 5+ years professional experience writing Java and/or Python code. • Proficiency in Java and web technologies, including type script, ES5/6, Babel Transpiler. • Demonstrated knowledge in cloud-computing, e.g. interacting with or developing in Kubernetes or Azure solutions/systems. • Experience in delegation and project leadership • Software development experience in a team environment, including understanding of modern development lifecycles. • Experience with analysis and algorithm development on complex NGS datasets. • Practical experience with version control tools (e.g. git) and agile approaches to development • Strong collaboration skills to work with internal team members and external collaborators. • Experience working with scientists in product development or research setting desirable. • Knowledge, background, or experience in molecular biology would be a significant asset.

Additional Information

Applicants should have a demonstrated track record in software development and in their application must provide examples of past accomplishments such as working software/webapps or open-source repositories.