Bioinformatician in Cancer Immunology

Institution/Company:
Princess Margaret Cancer Center
Location:
Toronto, ON, Canada
Job Type:
  • PhD
Degree Level Required:
Masters, PhD
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Bioinformatician in Cancer Immunology

A full-time position is available in the laboratory of Dr. David Brooks and Dr. Tracy McGaha at the Princess Margaret Cancer Center in Toronto, Canada. The successful candidate will work with the Brooks and McGaha Lab’s to support their bioinformatics efforts and to help organize, plan, analyze, and interpret the results from a variety of exciting projects that are currently ongoing and planned. The successful candidate will work on existing and ongoing CyTOF and single-cell RNA-sequencing data sets isolated from various components of the immune system and from genetically engineered mouse models of chronic infection and cancer.

Responsibilities:

The successful candidate will have all the tools required to accomplish their goals, including dedicated access to the hospital’s high-performance computing infrastructure, which is one of the top systems in Canada devoted to health care research. In addition to this, you will work with collaborating bioinformaticians at the Princess Margaret Bioinformatics and Computing Core.

Qualifications:

Candidates must have a PhD or MSc degree with experience in computer science, bioinformatics, biostatistics/statistics or genetics as well as hands-on experience in the use of Unix/Linux, R/Matlab, and statistical approaches (including Machine Learning techniques) to analyze and visualize genome-scale data sets. Preferred but not required are expertise in a scripting language (Python, Perl), best practices for software development (version control, etc.) and the use of high performance computing systems (eg. TORQUE) for analyzing large data sets. Hands-on experience processing and analyzing next-generation sequencing data and RNA-Sequencing data analysis is preferred. Experience with single cell sequencing data (Fluidigm C1, 10X, Dropseq etc.) and tools (Seurat, SCONE, SINGuLAR etc.) is a strong plus. Ideally, the successful candidate will have some familiarity with the basic principles of immunology.

Candidates should be highly motivated, possess excellent organizational, problem-solving and communication skills (both verbal and written) and have relevant publications in any of the fields of: immunology, cancer, genomics, statistics, or computational algorithms or tools. An exciting and fast paced place to work, we are looking for that ideal mixture of technical skills, biology, and creativity to grow and sustain bioinformatics efforts. Excellent salary and benefits will be provided.

  • How to Apply

    Applicants should respond by email with a curriculum vitae and cover letter to dbrooks@uhnresearch.ca and tracy.mcgaha@uhnresearch.ca