Scientific Associate - Bioinformatics analysis of human liver scRNAseq data

Institution/Company:
University Health Network
Location:
Toronto, ON, Canada
Job Type:
  • Staff
Degree Level Required:
PhD
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Scientific Associate - Bioinformatics analysis of human liver scRNAseq data

More than 250 million people are chronically infected with Hepatitis B virus (HBV) with no effective cure. The lab is part of the Toronto Centre for Liver Disease, one of the largest liver clinics in North America, with an active clinical trial research program testing novel hepatitis B therapies in Phase 2 studies. New studies are incorporating longitudinal liver sampling with single-cell RNA sequencing (scRNAseq) to better understand the intrahepatic immune response to novel treatments in the context of viral control and liver inflammation.

This is an opportunity to work with state-of-the-art data in the context of novel drugs in early stage clinical trials. The position will involve industry collaboration with the expectation of academic publication. There will also be internal opportunities for collaboration in our basic research projects focused HBV pathogenesis using similar samples.

The position includes a competitive salary and full benefits, including extended healthcare, dental and retirement plan.

About the University Health Network The University Health Network, where “above all else the needs of patients come first”, encompasses Toronto Rehabilitation Institute, Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre and the Michener Institute of Education at UHN. The breadth of research, the complexity of the cases treated, and the magnitude of its educational enterprise has made UHN a national and international resource for patient care, research and education. With a long tradition of groundbreaking firsts and a purpose of “Transforming lives and communities through excellence in care, discovery and learning”, the University Health Network (UHN), Canada’s largest research teaching hospital, brings together over 16,000 employees, more than 1,200 physicians, 8,000+ students, and many volunteers. UHN is a caring, creative place where amazing people are amazing the world.

University Health Network (UHN) is a research hospital affiliated with the University of Toronto and a member of the Toronto Academic Health Science Network. The scope of research and complexity of cases at UHN have made it a national and international source for discovery, education and patient care. Research across UHN’s five research institutes spans the full spectrum of diseases and disciplines, including cancer, cardiovascular sciences, transplantation, neural and sensory sciences, musculoskeletal health, rehabilitation sciences, and community and population health. Find out about our purpose, values and principles here.

Responsibilities:

The successful applicant will be expected to bring novel ideas and approaches to the bioinformatics research program and contribute to the scientific development of the analysis plan and manuscript preparation.

Primary responsibilities:

  1. Use new and existing single-cell RNA sequencing datasets to identify mechanisms of viral control and damage in the human liver.
  2. Help guide Ph.D. students and postdocs in project-specific bioinformatics analysis.

Qualifications:

• At minimum, a PhD in Immunology, Molecular Biology, Genetics, Microbiology, Mathematics, Statistics, Computer Science or related fields • At minimum, 2 years related experience • Published experience in scRNAseq data analysis • Interest in human immunology and willingness to learn about hepatitis B infection • Ability to work independently from home and onsite • Ability to advise/mentor fellow lab members in bioinformatics analysis strategies • Problem-solving initiative • Attention to detail and strong organizational skills • Good verbal and written communication skills